Ni3(N,N'-bis(salicylidene)-1,3-propanediaminate)2(OAc)2 | 1001339-46-3

• 英文名称: Ni3(N,N'-bis(salicylidene)-1,3-propanediaminate)2(OAc)2
• 英文别名: Ni3(SALPD)2(OAc)2
• CAS: 1001339-46-3；132485-55-3
• 化学式: C₃₈H₃₈N₄Ni₃O₈
• 分子量: 854.812
• InChiKey: RQPCLOUKGFXMIP-FOWFEXJWSA-H

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  N,N'-二亚水杨基-1,3-二氨基丙烷 、 nickel diacetate 以 甲醇 为溶剂， 生成 Ni3(N,N'-bis(salicylidene)-1,3-propanediaminate)2(OAc)2
  参考文献：
  名称：

  Synthesis, crystal structure and urease inhibitory activities of Schiff base metal complexes

  摘要：

  Six new transition metal complexes (1-6) with Schiff base were synthesized and crystallographically characterized. Their urease inhibitory activities were evaluated. Three of them showed potent inhibitions against jack bean urease. Mn(II) complex (2) possessed the best jbU inhibitory activity with IC50 of 8.30 +/- 0.93 mu M, which was much better than those of the corresponding ligand and control ion. The investigation on the stability constants and the structure-activity relationships of the complexes indicated that the complexes interacted with the enzyme in the whole complex forms rather than the free ions. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2006.12.011