(4-Methoxy-phenyl)-[1-pyridazin-4-yl-meth-(E)-ylidene]-amine | 187266-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Methoxy-phenyl)-[1-pyridazin-4-yl-meth-(E)-ylidene]-amine
• CAS: 187266-25-7
• 化学式: C₁₂H₁₁N₃O
• 分子量: 213.239
• InChiKey: XTECVYMBEBBZAT-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  47.37
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [(叔丁基二甲基甲硅烷基)氧基]乙酸乙酯 、 (4-Methoxy-phenyl)-[1-pyridazin-4-yl-meth-(E)-ylidene]-amine 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以12%的产率得到ethyl 2-[(tert-butyldimethylsilyl)oxy]-3-(4-methoxyphenylamino)-3-(4-pyridazinyl)propanoate
  参考文献：
  名称：

  Synthetic Building Blocks Containing the 1,2-Diazine Moiety: N- and O-Protected 3-(4-Pyridazinyl)isoserines

  摘要：

  The synthesis of pyridazinylglycidates and pyridazinylimines as potential precursors of pyridazinylisoserine derivatives, is described. Reaction of the imines (6a,b) with alpha-silyloxyketene acetals in the presence of zinc chloride led to isoserine derivatives (7a,b) and (8a,b). The mixtures of diastereoisomers obtained were separated and configurations were determined by X ray analysis.

  DOI：

  10.3987/com-96-7432
• 作为产物：
  描述：

  甲氧苯胺 、 哒嗪-4-甲醛 在 sodium sulfate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以94%的产率得到(4-Methoxy-phenyl)-[1-pyridazin-4-yl-meth-(E)-ylidene]-amine
  参考文献：
  名称：

  Synthetic Building Blocks Containing the 1,2-Diazine Moiety: N- and O-Protected 3-(4-Pyridazinyl)isoserines

  摘要：

  The synthesis of pyridazinylglycidates and pyridazinylimines as potential precursors of pyridazinylisoserine derivatives, is described. Reaction of the imines (6a,b) with alpha-silyloxyketene acetals in the presence of zinc chloride led to isoserine derivatives (7a,b) and (8a,b). The mixtures of diastereoisomers obtained were separated and configurations were determined by X ray analysis.

  DOI：

  10.3987/com-96-7432

文献信息

• Pyridazines<b>LXXVIII</b>On the reactivity of 4-methoxy-[(4-pyridazinyl)methylidene]aniline in ester enolate-imine condensation reactions
  作者：Gottfried Heinisch、Thierry Langer、Jacques Tonnel

  DOI：10.1002/jhet.5570330631

  日期：1996.11

  Reactions of the pyridazine derived aldimine 1 with lithium enolates of various α-substituted acetates were investigated. An unprecedented formation of the pyrido[3,4-d]pyridazine system due to nucleophilic attack of a carbanion species at the β-position of the pyridazine ring was observed.

  研究了哒嗪衍生的醛亚胺1与各种α-取代的乙酸酯的烯醇锂的反应。观察到由于在哒嗪环的β-位上碳负离子物种的亲核攻击而导致吡啶并[3,4- d ]哒嗪系统的空前形成。