tert-butyl N-[[2-[4-[2-(1-hydroxy-5-trimethylsilylpenta-2,4-diynyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]-N-methylcarbamate | 848641-94-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[[2-[4-[2-(1-hydroxy-5-trimethylsilylpenta-2,4-diynyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]-N-methylcarbamate
• CAS: 848641-94-1
• 化学式: C₂₉H₃₁NO₃SSi
• 分子量: 501.722
• InChiKey: OWMCXYRQITZXRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.44
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[[2-[4-[2-(1-hydroxy-5-trimethylsilylpenta-2,4-diynyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]-N-methylcarbamate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到tert-butyl N-methyl-N-[[2-[4-[2-(5-trimethylsilylpenta-2,4-diynoyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]carbamate
  参考文献：
  名称：

  Synthesis of indenothiophenone derivatives by cycloaromatization of non-conjugated thienyl tetraynes

  摘要：

  Non-conjugated thienyl tetrayne derivatives 1-3 are prepared as novel building block for the construction of indenothiophenone derivatives. Oxidation of 1-3, followed by cycloaromatization of the corresponding ketone derivatives 13-15 proceeds smoothly to afford indenothiophenone derivatives 16-21 in good yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.005
• 作为产物：
  描述：

  3-溴噻吩-2-甲醛 在 三丁基氯化锡 、 甲基锂 、 二异丙胺 、 lithium bromide 作用下， 以 乙醚 为溶剂， 生成 tert-butyl N-[[2-[4-[2-(1-hydroxy-5-trimethylsilylpenta-2,4-diynyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]-N-methylcarbamate
  参考文献：
  名称：

  Synthesis of indenothiophenone derivatives by cycloaromatization of non-conjugated thienyl tetraynes

  摘要：

  Non-conjugated thienyl tetrayne derivatives 1-3 are prepared as novel building block for the construction of indenothiophenone derivatives. Oxidation of 1-3, followed by cycloaromatization of the corresponding ketone derivatives 13-15 proceeds smoothly to afford indenothiophenone derivatives 16-21 in good yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.005