2-((S)-2-Amino-3-phenyl-propoxy)-propionic acid | 444884-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((S)-2-Amino-3-phenyl-propoxy)-propionic acid
• CAS: 444884-76-8
• 化学式: C₁₂H₁₇NO₃
• 分子量: 223.272
• InChiKey: UKABETAJTSJNGG-UMJHXOGRSA-N

反应信息

• 作为反应物：
  描述：

  氯甲酸-9-芴基甲酯 、 2-((S)-2-Amino-3-phenyl-propoxy)-propionic acid 在 sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propoxy]-propionic acid
  参考文献：
  名称：

  Stereoselective Synthesis of Ψ[CH 2 O] Pseudodipeptides and Conformational Analysis of a PheΨ[CH 2 O]Ala Containing Analogue of the Drug Desmopressin

  摘要：

  A method for synthesis of Xaapsi[CH2O]Ala/Gly pseudodipeptides in good yields and excellent diastereoselectivity from azido alcohols and (R)-2-chloropropionic acid or tort-butyl bromoacetate has been developed. Insertion of one of the pseudodipeptide building blocks in the peptide drug desmopressin revealed that methylene ether isosteres may have only a minor influence on the secondary structure of peptides. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00016-1
• 作为产物：
  描述：

  (S)-5-Benzyl-2-methyl-morpholin-3-one 在 盐酸 作用下， 生成 2-((S)-2-Amino-3-phenyl-propoxy)-propionic acid
  参考文献：
  名称：

  Stereoselective Synthesis of Ψ[CH 2 O] Pseudodipeptides and Conformational Analysis of a PheΨ[CH 2 O]Ala Containing Analogue of the Drug Desmopressin

  摘要：

  A method for synthesis of Xaapsi[CH2O]Ala/Gly pseudodipeptides in good yields and excellent diastereoselectivity from azido alcohols and (R)-2-chloropropionic acid or tort-butyl bromoacetate has been developed. Insertion of one of the pseudodipeptide building blocks in the peptide drug desmopressin revealed that methylene ether isosteres may have only a minor influence on the secondary structure of peptides. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00016-1