p-Brom-phenylpropenylsulfon | 20058-18-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Brom-phenylpropenylsulfon
• 英文别名: 1-Bromo-4-prop-1-enylsulfonylbenzene
• CAS: 20058-18-8
• 化学式: C₉H₉BrO₂S
• 分子量: 261.139
• InChiKey: RMPNGDZBTAZMRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(allylsulfonyl)-4-bromobenzene 在 三乙胺 作用下， 生成 p-Brom-phenylpropenylsulfon
  参考文献：
  名称：

  Mikhailova,V.N. et al., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 1391 - 1394

  摘要：

  DOI：

文献信息

• 14-membered ketolides and methods of their preparation and use
  申请人：President and Fellows of Harvard College

  公开号：US10633407B2

  公开（公告）日：2020-04-28

  Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

  本文提供了通过东半部和西半部分子的偶联，然后进行大环化和任选官能化来制备新的 14 元酮苷的方法。还提供了合成这些酮苷的中间体，包括东半部分和西半部分。还提供了使用这些酮苷治疗传染性疾病和炎症的药物组合物和方法。
• 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE
  申请人：President and Fellows of Harvard College

  公开号：US20170305953A1

  公开（公告）日：2017-10-26

  Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.