2-Isopropenyl-tetrahydropyran | 99114-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-Isopropenyl-tetrahydropyran
• 英文别名: 2-Prop-1-en-2-yloxane
• CAS: 99114-99-5
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: ONHYBNYWPASUPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-2-Methylhept-2-ene-1,7-diol 在 cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate 、 allyl (R)-6-(2-chloronaphthalen-1-yl)-5-methylpyridine-2-carboxylate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 1.0h， 以87%的产率得到2-Isopropenyl-tetrahydropyran
  参考文献：
  名称：

  钌配合物催化ω-羟基烯丙醇的不对称脱水环化

  摘要：

  已经设计并合成了新的轴向手性配体及其烯丙基酯。这些配体与[CpRu（CH 3 CN）3 ] PF 6的结合实现了ω-羟基烯丙醇的高效分子内脱水环化反应，得到对映体比高达99：1的α-烯基取代的环状醚没有活化烯丙基部分（参见方案； Cp ＝环戊二烯基，naph ＝萘基，py ＝吡啶）。

  DOI：

  10.1002/anie.200904671

文献信息

• INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
  申请人：Hurley Timothy Brian

  公开号：US20090325948A1

  公开（公告）日：2009-12-31

  The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection.

  本发明涉及选择性和/或有效抑制UPPS的化合物。除了抑制UPPS的化合物外，本发明还提供包含这些化合物的药物组合物以及使用这些化合物治疗细菌性疾病，如细菌感染的方法。
• LIGAND FOR ASYMMETRIC SYNTHESIS CATALYST, AND PROCESS FOR PRODUCTION OF ALPHA-ALKENYL CYCLIC COMPOUND USING SAME
  申请人：Kitamura Masato

  公开号：US20120220780A1

  公开（公告）日：2012-08-30

  Disclosed are: a ligand for an asymmetric synthesis catalyst; and a process for producing an α-alkenyl cyclic compound using the ligand. Specifically disclosed are: a ligand for an asymmetric synthesis catalyst, which is represented by any one of formulae (1) to (4) [wherein R 1 represents —Cl or —Br; R 2 represents —CH 3 or —CF 3 ; and R 3 represents —CH 2 —CH═CH 2 or —H]; and a process for producing an α-alkenyl cyclic compound using the ligand.

  公开了一种用于不对称合成催化剂的配体以及使用该配体制备α-烯丙基环状化合物的方法。具体公开了一种用于不对称合成催化剂的配体，其由公式（1）到（4）中的任一式所表示[其中R1代表—Cl或—Br；R2代表—CH3或—CF3；R3代表—CH2—CH═ 或—H]，以及使用该配体制备α-烯丙基环状化合物的方法。
• US8822696B2
  申请人：——

  公开号：US8822696B2

  公开（公告）日：2014-09-02
• [EN] RUBBER COMPOUND BASED ON HIGH-MOLECULAR METHYLVINYL-SILOXANE RUBBER<br/>[FR] MELANGE CAOUTCHOUTE A BASE DE CAOUTCHOUC DE METHYLVINYLOXANE A POIDS MOLECULAIRE ELEVE
  申请人：ZAKRYTOE AKTSIONERNOE OBSCHEST

  公开号：WO2004056923A1

  公开（公告）日：2004-07-08

  The invention relates to chemical engineering, in particular to rubber compounds based on siloxane rubbers and can be used for producing electroinsulating tubes and insulating cable jackets, polymeric insulator for high-voltage power lines, general rubber products and materials contacting gasoline, organic solvent and mineral oils. The inventive rubber compound based on high-molecular methylvinyl-siloxane rubber used in a quantity of 70-80 mass fractions, contains low-molecular methylvinyl-siloxane rubber of a formula HO[(CH3)2 SiO] m[(CH3)(CH2 CH)SiO]nH, wherein m, n-molar fraction of links, wherein m+n=100 (mol.%), m=98.5-99.85 (mol.%), n=0.15-1.5 (mol.%), with a molecular mass of 20-70 thousand units in a quantity of 20-30 mass fractions, comprises 170-200 mass fractions of powdery silica, 40-50 mass fractions of aerosil, 8-10 mass fractions of antistructure forming agent-α, φ-dihydroxipoly-dimethylsiloxane and 1.5-2.0 mass fractions of organic peroxide. Vulcanisates of the rubber compound exhibit a high resistance to gasoline, organic solvents and mineral oils.
• [EN] INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE<br/>[FR] INHIBITEURS DE L'UNDÉCAPRÉNYL PYROPHOSPHATE SYNTHASE
  申请人：NOVARTIS AG

  公开号：WO2008014307A2

  公开（公告）日：2008-01-31

  [EN] The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection.
  [FR] L'invention concerne des composés qui sont des inhibiteurs sélectifs et/ou puissants de l'undécaprényl pyrophosphate systhase (UPPS). Outre les composants qui inhibent l'UPPS, l'invention concerne des compositions pharmaceutiques comprenant ces composés ainsi que des procédés d'utilisation de ces composés dans le traitement de maladies bactériennes, telles qu'une infection bactérienne.