N-[(3-methoxyphenyl)methyl]-N,3-dimethylaniline | 1607801-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(3-methoxyphenyl)methyl]-N,3-dimethylaniline
• CAS: 1607801-93-3
• 化学式: C₁₆H₁₉NO
• 分子量: 241.333
• InChiKey: MBKCIEQCZJWWSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-溴甲基苯 、 N-甲基-3-甲氧基苄胺 在 (1-甲基-2,2-二苯基环丙基)二叔丁基膦 、 bis(η3-allyl-μ-chloropalladium(II)) 、 sodium t-butanolate 作用下， 以 水 为溶剂， 反应 16.0h， 以70%的产率得到N-[(3-methoxyphenyl)methyl]-N,3-dimethylaniline
  参考文献：
  名称：

  Buchwald–Hartwig reactions in water using surfactants

  摘要：

  Examination of the scope and limitation of the Buchwald-Hartwig cross-coupling reaction in micellar medium is reported. An array of aryl or heteroaryl halides were coupled to diverse nitrogen coupling partners using a combination of [(allyl)PdCl](2) and cBRIDP to afford the corresponding products in moderate to excellent yields. 30 examples are reported, including polar solid and fairly water-soluble organic substrates/reagents. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.083

文献信息

• Buchwald–Hartwig reactions in water using surfactants
  作者：Christophe Salomé、Patrick Wagner、Maud Bollenbach、Frédéric Bihel、Jean-Jacques Bourguignon、Martine Schmitt

  DOI：10.1016/j.tet.2014.03.083

  日期：2014.5

  Examination of the scope and limitation of the Buchwald-Hartwig cross-coupling reaction in micellar medium is reported. An array of aryl or heteroaryl halides were coupled to diverse nitrogen coupling partners using a combination of [(allyl)PdCl](2) and cBRIDP to afford the corresponding products in moderate to excellent yields. 30 examples are reported, including polar solid and fairly water-soluble organic substrates/reagents. (C) 2014 Elsevier Ltd. All rights reserved.