Ethyl 3-(benzotriazol-1-yl)-2-oxopropanoate | 461639-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: Ethyl 3-(benzotriazol-1-yl)-2-oxopropanoate
• CAS: 461639-21-4
• 化学式: C₁₁H₁₁N₃O₃
• 分子量: 233.227
• InChiKey: DVLTXLMJYSHSRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-甲氧基亚苯基肼 、 Ethyl 3-(benzotriazol-1-yl)-2-oxopropanoate 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  铜催化二氮杂二烯与烯醇醚的对映体选择性电子逆杂Diels-Alder反应：手性哒嗪的高效合成

  摘要：

  AbstractA highly efficient and enantioselective inverse electron‐demand hetero‐Diels–Alder reaction of in situ generated 1,2‐diaza‐1,3‐dienes with enol ethers has been developed with the use of a chiral copper/bisoxazoline complex as the catalyst. The reaction exhibits high enantioselectivity (up to 90% ee) and provides a robust and powerful method to synthesize a variety of structurally diverse and densely substituted chiral pyridazine derivatives in good to excellent yields.magnified image

  DOI：

  10.1002/adsc.201300723

文献信息

• Maleimide derivatives, pharmaceutical compositions amd methods for treatment of cancer
  申请人：ArQule, Inc.

  公开号：EP2289892A1

  公开（公告）日：2011-03-02

  The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or pyrroloquinolinyl-pyrrolidine-2,5-dione compound of the present invention.

  本发明涉及吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯烷-2,5-二酮化合物，以及这些化合物的制备方法。本发明还涉及包含吡咯喹啉基吡咯-2,5-二酮化合物和吡咯喹啉基吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了治疗细胞增殖性疾病（如癌症）的方法，即向有需要的受试者施用治疗有效量的本发明的吡咯喹啉基吡咯-2,5-二酮化合物或吡咯喹啉基吡咯烷-2,5-二酮化合物。
• Copper‐Catalyzed Enantioselective Inverse Electron‐Demand Hetero‐Diels–Alder Reactions of Diazadienes with Enol Ethers: Efficient Synthesis of Chiral Pyridazines
  作者：Shuang Gao、Jia‐Rong Chen、Xiao‐Qiang Hu、Hong‐Gang Cheng、Liang‐Qiu Lu、Wen‐Jing Xiao

  DOI：10.1002/adsc.201300723

  日期：2013.12.16

  AbstractA highly efficient and enantioselective inverse electron‐demand hetero‐Diels–Alder reaction of in situ generated 1,2‐diaza‐1,3‐dienes with enol ethers has been developed with the use of a chiral copper/bisoxazoline complex as the catalyst. The reaction exhibits high enantioselectivity (up to 90% ee) and provides a robust and powerful method to synthesize a variety of structurally diverse and densely substituted chiral pyridazine derivatives in good to excellent yields.magnified image