N-(1H-benzoimidazol-2-yl)-N'-benzyl-ethane-1,2-diamine | 34658-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-(1H-benzoimidazol-2-yl)-N'-benzyl-ethane-1,2-diamine
• 英文别名: N'-(1H-benzimidazol-2-yl)-N-benzylethane-1,2-diamine
• CAS: 34658-91-8
• 化学式: C₁₆H₁₈N₄
• 分子量: 266.346
• InChiKey: LFUFZCOJBUDOJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  52.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS METHIONYL T-RNA SYNTHETASE INHIBITORS<br/>[FR] DERIVES DE BENZIMIDAZOLE ET LEUR UTILISATION COMME INHIBITEURS DE LA METHIONYL-ARN-T SYNTHETASE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000071522A1

  公开（公告）日：2000-11-30

  Compounds of formula (I) in which R1 is an optionally substituted aryl or an optionally substituted heteroaryl ring; (R2)m is hydrogen or selected substituents; X is CH2 or CHR3 in which R3 is C¿(1-6)? alkyl or is linked to the orthoposition of an aryl or heteroaryl ring of R?1¿ to form a 5 to 7 membered ring optionally including oxygen or nitrogen as a ring atom; Y is C¿(1-3)? alkylene or C(4-6) cycloalkylene; are inhibitors of the bacterial enzyme S aureus methionyl t-RNA synthetase and are of use in treating bacterial infections.