(+/-)-10-ethyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6h-pyrimido[1,2-a]azepin-4-one | 1202692-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (+/-)-10-ethyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6h-pyrimido[1,2-a]azepin-4-one
• 英文别名: 10-ethyl-2-pyridin-4-yl-7,8,9,10-tetrahydro-6H-pyrimido[1,2-a]azepin-4-one
• CAS: 1202692-29-2
• 化学式: C₁₆H₁₉N₃O
• 分子量: 269.346
• InChiKey: HNLWZZCJKLXRCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED ALKYL PYRIMIDIN-4-ONE DERIVATIVES
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2321315A2

  公开（公告）日：2011-05-18
• JP2011525908A
  申请人：——

  公开号：JP2011525908A

  公开（公告）日：2011-09-29
• [EN] SUBSTITUTED ALKYL PYRIMIDIN-4-ONE DERIVATIVES<br/>[FR] DÉRIVÉS PYRIMIDIN-4-ONE À SUBSTITUTION ALKYLE
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2009156864A2

  公开（公告）日：2009-12-30

  A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof (I), wherein, X represents a methylene, NH, a nitrogen atom substituted by a C(O)-O- (C1-6-alkyl) group; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted by a C1-6 alkyl group, a C1-6 alkoxy group or a halogen atom; R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R3 represents a C1-6 alkyl group optionally substituted, R4 represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group; m represents 1 to 2 when X is a methylene or m represents 2 when X is NH, a nitrogen atom substituted by a C(O)-O-(C1-6-alkyl) group; in the form of a free base or of an addition salt with an acid. Use in therapeutic