4-甲基-7H-呋喃并(3,2-g)(1)苯并吡喃-7-酮 | 15912-89-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基-7H-呋喃并(3,2-g)(1)苯并吡喃-7-酮
• 英文名称: 5-methylpsoralen
• 英文别名: 4-Methylfuro[3,2-g]chromen-7-one
• CAS: 15912-89-7
• 化学式: C₁₂H₈O₃
• 分子量: 200.194
• InChiKey: CDPRWGCJWLAYAD-UHFFFAOYSA-N

物化性质

• 熔点：
  162-163 °C
• 沸点：
  381.9±30.0 °C(Predicted)
• 密度：
  1.332±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  4-甲基-7H-呋喃并(3,2-g)(1)苯并吡喃-7-酮 生成 4-METHYL-6-ACETOXY-5-BENZOFURANACRYLIC ACID
  参考文献：
  名称：

  Photosensitizing benzofuranacrylics

  摘要：

  本发明涉及5-苯并呋喃丙烯酸化合物，优选在苯并呋喃环系统中具有较低烷基取代，该化合物具有光敏活性，特别是口服和局部活性，同时具有低毒性。

  公开号：

  US04279922A1
• 作为产物：
  描述：

  C₁₂H₁₀O₄ 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 4.0h， 以75 mg的产率得到4-甲基-7H-呋喃并(3,2-g)(1)苯并吡喃-7-酮
  参考文献：
  名称：

  Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure–activity relationship study

  摘要：

  Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of la were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 mu g/mL) than 1a (MIC = 6.25 mu g/mL), and is even potent than the positive control metronidazole (MIC = 0.50 mu g/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of la have also led to an outline of structure-activity relationship. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.045

文献信息

• Device and method for photoactivation
  申请人：Cerus Corporation

  公开号：US20030170141A1

  公开（公告）日：2003-09-11

  A device comprising a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.

  一个装置包括一个光源、一个样品支架和一个温度控制隔室。样品支架被定位以支持多个样品容器，以便被光源照射。温度控制隔室保持样品容器的温度在所需范围内。光源、样品支架和温度控制隔室都包含在不透明的外壳内。
• A device for nucleic acid sterilization
  申请人：ISAACS, Stephen T.

  公开号：EP0890363A2

  公开（公告）日：1999-01-13

  The invention relates to a device, comprising means for providing electromagnetic radiation (101-106; 201-206; 301-308); means for supporting a sample (109;315) in a fixed relationship with said radiation providing means during irradiation; a housing (100;200;300) for containing said radiation providing means; and means for maintaining the temperature of said sample within a desired temperature range during said irradiation comprising a chamber (107;207;309) positioned interior to said housing and in a fixed relationship to said radiation providing means.

  本发明涉及一种设备，包括用于提供电磁辐射的装置（101-106；201-206；301-308）；用于在辐照期间支撑与所述辐射提供装置保持固定关系的样品（109；315）的装置；用于容纳所述辐射提供装置的外壳（100；200；300）；以及用于在所述辐照期间将所述样品的温度保持在所需温度范围内的装置，该装置包括一个位于所述外壳内部并与所述辐射提供装置保持固定关系的腔室（107；207；309）。
• REDUCED SODIUM FOOD PRODUCTS
  申请人：GENERAL MILLS, INC.

  公开号：EP3732994A1

  公开（公告）日：2020-11-04

  Naturally-derived compounds having various structures elicit the perception of salty taste or enhance the perception of salty taste of a salt. Food products may include such salty compounds, which may be used to reduce the sodium content, while imparting a similar level of saltiness.

  具有各种结构的天然衍生化合物可引起咸味感知或增强盐的咸味感知。食品中可能含有此类咸味化合物，可用于降低钠含量，同时赋予类似的咸味。
• ACTIVATION COMPOUNDS AND METHODS FOR NUCLEIC ACID STERILIZATION
  申请人：ISAACS, Stephen T.

  公开号：EP0497921A1

  公开（公告）日：1992-08-12
• EP0497921A4
  申请人：——

  公开号：EP0497921A4

  公开（公告）日：1995-06-28