5-methyl-3-(p-tolyl)pyridazine | 37385-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-methyl-3-(p-tolyl)pyridazine
• 英文别名: 5-Methyl-3-p-tolylpyridazin
• CAS: 37385-35-6
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: IVCYKWKOACIJOP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-ethyl-4-oxo-4-(4-phenylphenyl)butanal 在 盐酸肼 、 碳酸氢钠 作用下， 以 乙腈 为溶剂， 以73 %的产率得到5-methyl-3-(p-tolyl)pyridazine
  参考文献：
  名称：

  Iridium(iii)-catalyzed photoredox cross-coupling of alkyl bromides with trialkyl amines: access to α-alkylated aldehydes

  摘要：

  A C(sp3)–C(sp3) cross coupling approach based on an iridium-photocatalytic radical process has been developed for the synthesis of α-alkylated aldehydes from alkyl bromides and trialkyl amines.

  DOI：

  10.1039/d4cc01043d

文献信息

• Copper-Catalyzed Aerobic 6-Endo-Trig Cyclization of β,γ-Unsaturated Hydrazones for the Divergent Synthesis of Dihydropyridazines and Pyridazines
  作者：Zhenwei Fan、Zhangjin Pan、Liangsen Huang、Jiajia Cheng

  DOI：10.1021/acs.joc.9b00228

  日期：2019.4.5

  A divergent synthetic strategy to 1,6-dihydropyridazines and pyridazines through Cu(II)-catalyzed controllable aerobic 6-endo-trig cyclization was developed. The selectivity can be rationally tuned via the judicious choice of reaction solvent. It was found that the 1,6-dihydropyridazines were obtained in moderate to high yields with CH3CN as the reaction solvent, whereas employment of AcOH directly

  通过Cu（II）催化可控的好氧6-endo-trig环化反应，开发了一种合成1,6-二氢哒嗪和哒嗪的合成策略。可以通过明智地选择反应溶剂来合理地调节选择性。已经发现，以CH 3 CN作为反应溶剂可以中等至高收率获得1,6-二氢哒嗪，而使用AcOH直接以高达92％的收率获得哒嗪，这可能是由于原位生成的氧化所致。 1,6-二氢哒嗪。
• Synthesis of 1,4,5,6-tetrahydropyridazines and pyridazines <i>via</i> transition-metal-free (4 + 2) cycloaddition of alkoxyallenes with 1,2-diaza-1,3-dienes
  作者：Qi Wu、Pan-Lin Shao、Yun He

  DOI：10.1039/c9ra02712b

  日期：——

  We developed an economical and practical protocol for the synthesis of 1,4,5,6-tetrahydropyridazines. A diverse range of alkoxyallenes and 1,2-diaza-1,3-dienes undergo (4 + 2) cycloaddition to generate the desired products in excellent yields. The high efficiency, wide substrate scope and good functional group tolerance of this process, coupled with operational simplicity, render the method synthetically

  我们开发了一种经济实用的 1,4,5,6-四氢哒嗪合成方案。各种烷氧基丙二烯和 1,2-二氮杂-1,3-二烯经过 (4 + 2) 环加成反应，以优异的收率生成所需的产物。该工艺的高效率、宽底物范围和良好的官能团耐受性，加上操作简单，使该方法具有综合吸引力。从 1,4,5,6-四氢哒嗪制备各种哒嗪也证明了环加成的效用。