4-Methyl-2-(methylamino)pyrimidine-5-carboxamide | 17436-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Methyl-2-(methylamino)pyrimidine-5-carboxamide
• CAS: 17436-73-6
• 化学式: C₇H₁₀N₄O
• 分子量: 166.18
• InChiKey: YHHMPUVFNNFOQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA NICOTINAMIDE N-MÉTHYLTRANSFÉRASE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：HARVARD COLLEGE

  公开号：WO2021163683A1

  公开（公告）日：2021-08-19

  Disclosed are compounds and pharmaceutically acceptable salts thereof, which are useful as inhibitors nicotinamide N-methyltransferase (NNMT). Also disclosed are pharmaceutical compositions comprising a compound disclosed herein. Related methods of treating cancer in a subject and methods of inhibiting tumor growth in subject are also disclosed.