2-tert-Butoxycarbonylamino-9H-fluorene-9-carboxylic acid | 174136-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-tert-Butoxycarbonylamino-9H-fluorene-9-carboxylic acid
• CAS: 174136-16-4
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: UYBHYIBIUCAJSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  75.63
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-tert-Butoxycarbonylamino-9H-fluorene-9-carboxylic acid 在 sodium tetrahydroborate 、 氯甲酸乙酯 作用下， 反应 0.5h， 生成
  参考文献：
  名称：

  Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9h-fluoren-9-ylmethyl ester: A convenient transient-biotinylation reagent for use in affinity chromatography

  摘要：

  Stepwise synthesis of hydrophobic peptides frequently yields deletion products, which often require extensive purification and identification We synthesized a new transient-biotinylation reagent 9, which was conveniently used in affinify chromatography of crude products (exemplified by 11-I and 11-II), to afford pure peptides (15-1 and 15-11, respectively). Unlike conventional affinity chromatography, reagent 9 leads to free N-terminal peptides, which are thus amenable to further chemical manipulations.

  DOI：

  10.1016/0040-4039(95)01964-j
• 作为产物：
  描述：

  2-氨基芴 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 2-tert-Butoxycarbonylamino-9H-fluorene-9-carboxylic acid
  参考文献：
  名称：

  Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9h-fluoren-9-ylmethyl ester: A convenient transient-biotinylation reagent for use in affinity chromatography

  摘要：

  Stepwise synthesis of hydrophobic peptides frequently yields deletion products, which often require extensive purification and identification We synthesized a new transient-biotinylation reagent 9, which was conveniently used in affinify chromatography of crude products (exemplified by 11-I and 11-II), to afford pure peptides (15-1 and 15-11, respectively). Unlike conventional affinity chromatography, reagent 9 leads to free N-terminal peptides, which are thus amenable to further chemical manipulations.

  DOI：

  10.1016/0040-4039(95)01964-j