2-[3-Chloro-4-(4-hydroxy-phenoxy)-5-methyl-phenyl]-2H-[1,2,4]triazine-3,5-dione | 660407-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-Chloro-4-(4-hydroxy-phenoxy)-5-methyl-phenyl]-2H-[1,2,4]triazine-3,5-dione
• 英文别名: 2-[3-Chloro-4-(4-hydroxyphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dione；2-[3-chloro-4-(4-hydroxyphenoxy)-5-methylphenyl]-1,2,4-triazine-3,5-dione
• CAS: 660407-98-7
• 化学式: C₁₆H₁₂ClN₃O₄
• 分子量: 345.742
• InChiKey: MAWFKOMFUOUUAR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-[3-Chloro-4-(4-hydroxy-phenoxy)-5-methyl-phenyl]-2H-[1,2,4]triazine-3,5-dione 在 ClSO₂H 作用下， 生成
  参考文献：
  名称：

  Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

  摘要：

  In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based thyromimetics that possess up to 100-fold selectivities for binding and functional activation of the beta(1)-isoform of the thyroid receptor family. Structure-activity relationship studies on the 3,5- and 3'-positions provided compounds with enhanced TRbeta affinity and selectivity. Key binding interactions between the 6-azauracil moiety and the receptor have been determined through of X-ray crystallographic analysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00947-2
• 作为产物：
  描述：

  2-{3-chloro-4-[4-methoxy-phenoxy]-5-methyl-phenyl}-2H-[1,2,4]triazine-3,5-dione 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 生成 2-[3-Chloro-4-(4-hydroxy-phenoxy)-5-methyl-phenyl]-2H-[1,2,4]triazine-3,5-dione
  参考文献：
  名称：

  Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

  摘要：

  In this communication, we wish to describe the discovery of a novel series of 6-azauracil-based thyromimetics that possess up to 100-fold selectivities for binding and functional activation of the beta(1)-isoform of the thyroid receptor family. Structure-activity relationship studies on the 3,5- and 3'-positions provided compounds with enhanced TRbeta affinity and selectivity. Key binding interactions between the 6-azauracil moiety and the receptor have been determined through of X-ray crystallographic analysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00947-2