ethyl 6-(4-(bromomethyl)phenyloxy)-hexanoate | 243648-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 6-(4-(bromomethyl)phenyloxy)-hexanoate
• CAS: 243648-17-1
• 化学式: C₁₅H₂₁BrO₃
• 分子量: 329.234
• InChiKey: MDAIEEPHLMZSNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  19.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  ethyl 6-(4-(bromomethyl)phenyloxy)-hexanoate 在 氢氧化钾 、 18-冠醚-6 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 xylene 为溶剂， 生成
  参考文献：
  名称：

  Self-Assembly of Styryl Naphthalene Amphiphiles in Aqueous Dispersions and Interfacial Films:  Aggregate Structure, Assembly Properties, Photochemistry, and Photophysics

  摘要：

  A study of phospholipid and fatty acid amphiphiles containing the isomeric trans-alpha- and beta-styrylnaphthalene chromophores is reported. On the basis of simulations for Langmuir films of fatty acids terminated with the two chromophores, it was anticipated that the beta-styrylnaphthalene fatty acids should be able to Pack into compact layers, having an extended glide or herringbone arrangement similar to those observed for corresponding stilbene, tolan, or azobenzene amphiphiles. In contrast, the simulations suggested that such an arrangement might be precluded on steric grounds for the isomeric alpha-styrylnaphthalene derivatives. The experimental studies carried out indicate that the beta-styrylnaphthalene fatty acids and phospholipids do in fact exhibit assembly properties and photophysical behavior similar to that observed for the stilbene and tolan amphiphiles; thus we find evidence for aggregates having similar "signatures" to those observed previously for both films at the air-water interface and aqueous suspensions. The behavior of the alpha-styrylnaphthalene amphiphiles is much more complex. Whereas aqueous dispersions of the phospholipid and highly compressed films at the air-water interface suggest the presence of weak aggregates (possibly dimers) having a translation or face-to-face structure, studies of the fatty acid derivative at the air-water interface suggest that the alpha fatty acid may form a "pinwheel" or herringbone cluster before compression such that drastically different photochemistry and photophysics is observed as a function of compression.

  DOI：

  10.1021/jp990857m
• 作为产物：
  描述：

  Ethyl 6-(4-methylphenoxy)hexanoate 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 以69%的产率得到ethyl 6-(4-(bromomethyl)phenyloxy)-hexanoate
  参考文献：
  名称：

  Self-Assembly of Styryl Naphthalene Amphiphiles in Aqueous Dispersions and Interfacial Films:  Aggregate Structure, Assembly Properties, Photochemistry, and Photophysics

  摘要：

  A study of phospholipid and fatty acid amphiphiles containing the isomeric trans-alpha- and beta-styrylnaphthalene chromophores is reported. On the basis of simulations for Langmuir films of fatty acids terminated with the two chromophores, it was anticipated that the beta-styrylnaphthalene fatty acids should be able to Pack into compact layers, having an extended glide or herringbone arrangement similar to those observed for corresponding stilbene, tolan, or azobenzene amphiphiles. In contrast, the simulations suggested that such an arrangement might be precluded on steric grounds for the isomeric alpha-styrylnaphthalene derivatives. The experimental studies carried out indicate that the beta-styrylnaphthalene fatty acids and phospholipids do in fact exhibit assembly properties and photophysical behavior similar to that observed for the stilbene and tolan amphiphiles; thus we find evidence for aggregates having similar "signatures" to those observed previously for both films at the air-water interface and aqueous suspensions. The behavior of the alpha-styrylnaphthalene amphiphiles is much more complex. Whereas aqueous dispersions of the phospholipid and highly compressed films at the air-water interface suggest the presence of weak aggregates (possibly dimers) having a translation or face-to-face structure, studies of the fatty acid derivative at the air-water interface suggest that the alpha fatty acid may form a "pinwheel" or herringbone cluster before compression such that drastically different photochemistry and photophysics is observed as a function of compression.

  DOI：

  10.1021/jp990857m

文献信息

• Cap and Capture−Release Techniques Applied to Solid-Phase Synthesis of Oligosaccharides
  作者：Jian Wu、Zhongwu Guo

  DOI：10.1021/jo060255g

  日期：2006.9.1

  paper reports a new strategy for oligosaccharide synthesis by combining solid-phase methods with cap and capture−release separation techniques, using the p-(5-(ethoxycarbonyl)pentyloxy)benzyl group (CPB) as a tag for the capture of desired oligosaccharides. After a complex carbohydrate mixture was obtained by solid-phase synthesis, the desired oligosaccharide containing a free carboxyl group derived from

  本文报告了一种新的寡糖合成策略，该方法通过将固相方法与封端和捕获释放分离技术相结合，使用对-（5-（乙氧基羰基）戊氧基）苄基（CPB）作为捕获所需寡糖的标签。通过固相合成获得复杂的碳水化合物混合物之后，将所需的含有源自CPB的游离羧基的寡糖连接至氨基树脂。负载的树脂易于通过过滤与副产物分离，最后用酸处理以释放出纯的寡糖产物。