(2-ethyl-pyrimidin-4-yl)-methyl-amine | 52698-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2-ethyl-pyrimidin-4-yl)-methyl-amine
• 英文别名: 2-ethyl-N-methylpyrimidin-4-amine
• CAS: 52698-67-6
• 化学式: C₇H₁₁N₃
• 分子量: 137.184
• InChiKey: USNOFKSOYQEXRC-UHFFFAOYSA-N

物化性质

• 沸点：
  236.8±13.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
  申请人：——

  公开号：US20040171881A1

  公开（公告）日：2004-09-02

  Disclosed are compounds of the formula 1 wherein the variables R N , R C , R 1 , R 25 , R 2 , and R 3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

  本文披露了式1的化合物，其中变量RN、RC、R1、R25、R2和R3的定义如本文所述。这些化合物具有抑制β-分泌酶的活性，因此可用于治疗多种疾病，如阿尔茨海默病。
• N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES
  申请人：Elan Pharmaceuticals, Inc.

  公开号：EP1453789A2

  公开（公告）日：2004-09-08
• US7176242B2
  申请人：——

  公开号：US7176242B2

  公开（公告）日：2007-02-13
• US7727997B2
  申请人：——

  公开号：US7727997B2

  公开（公告）日：2010-06-01
• [EN] N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES<br/>[FR] DERIVES 1,3-DIAMINO-2-HYDROXYPROPANE N-N'-SUBSTITUES
  申请人：ELAN PHARM INC

  公开号：WO2003040096A2

  公开（公告）日：2003-05-15

  Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.