4-(β-Phenyl-ethylamino)-6-chlor-pyrimidin | 19808-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-(β-Phenyl-ethylamino)-6-chlor-pyrimidin
• 英文别名: (6-chloro-pyrimidin-4-yl)-phenethyl-amine；4-Pyrimidinamine, 6-chloro-N-(2-phenylethyl)-；6-chloro-N-(2-phenylethyl)pyrimidin-4-amine
• CAS: 19808-07-2
• 化学式: C₁₂H₁₂ClN₃
• mdl: MFCD14587459
• 分子量: 233.7
• InChiKey: KBNSEPJEQUFZKS-UHFFFAOYSA-N

物化性质

• 沸点：
  423.4±35.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS<br/>[FR] DÉRIVÉS AZA-INDOLIQUES UTILISÉS COMME INHIBITEURS DE RHO-KINASE
  申请人：CHIESI FARM SPA

  公开号：WO2019238628A1

  公开（公告）日：2019-12-19

  The invention relates to compounds of formula (I) inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

  该发明涉及抑制Rho激酶的式(I)化合物，这些化合物是吡唑吲哚衍生物，制备这类化合物的方法，含有它们的药物组合物以及它们的治疗用途。特别是该发明的化合物可能在治疗与ROCK酶机制相关的许多疾病中有用，如包括哮喘、慢性阻塞性肺病（COPD）、特发性肺纤维化（IPF）和肺动脉高压（PAH）在内的肺部疾病。
• 4-ALKANOYLAMINO-3-PYRAZOLONE DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20150011552A1

  公开（公告）日：2015-01-08

  The present invention provides a compound which enhances the production of erythropoietin. The present invention provides, for example, a compound represented by the formula (1) wherein R 1 : -Q 1 , -Q 1 -X-Q 2 , or -Q 1 -X-Q 2 -Y-Q 3 : a monocyclic or bicyclic aromatic heterocyclic group; Q 2 , Q 3 : an aromatic hydrocarbon ring group or a monocyclic aromatic heterocyclic group; X: —CONH—, —CONHCH 2 —, —CH 2 OCH 2 —, —NHCH 2 CH 2 —, or the like; Y: a single bond, —O—, —(CH 2 ) n —, or —O—(CH 2 ) n —; m, n: an integer from 1 to 3; R 2 : H or an alkyl group; and R 3 : H, an alkoxycarbonyl group, a carboxy group, an aromatic hydrocarbon ring group, or a monocyclic aromatic heterocyclic group.

  本发明提供了一种增强促红细胞生成素产生的化合物。例如，本发明提供了一种由式（1）表示的化合物，其中R1：-Q1，-Q1-X-Q2，或-Q1-X-Q2-Y-Q3：单环或双环芳香杂环基团；Q2，Q3：芳香烃环基团或单环芳香杂环基团；X：—CONH—，—CONH —，— O —，—NH —，或类似物；Y：一个单键，—O—，—（CH2）n—，或—O—（ ）n—；m，n：为1到3的整数；R2：H或烷基基团；和R3：H，烷氧羰基团，羧基团，芳香烃环基团，或单环芳香杂环基团。
• 4-(3-Butynyl)Aminopyrimidine Derivatives as Pest Control Agents for Agricultural and Horticultural Use
  申请人：Sakai Masaaki

  公开号：US20120136150A1

  公开（公告）日：2012-05-31

  Novel 4-(3-butynyl)aminopyrimidine derivatives represented by general formula [I] are useful as pest control agents. In general formula [I], R 1 is a mono- or bi-cyclic ring which may contain 0 to 3 heteroatoms, for example, phenyl or oxazolyl; R 2 is a hydrogen atom, —R, —OR, —C(O)OR, —C(O)NHR, —CONR 2 (wherein R is straight-chain or branched C 1-8 alkyl, or the like), hydroxyalkyl, or the like; R 3 is a hydrogen atom, a halogen atom, acyloxy represented by (straight-chain or branched C 1-8 aliphatic hydrocarbon group) —CO—O—, or the like; and R 4 is a hydrogen atom, a halogen atom, C 1-6 alkyl, or the like, or alternatively, R 4 and R 3 together with the carbon atoms on the pyrimidine ring may form a thiophene ring, a pyrrole ring, an imidazole ring, a benzene ring, a pyrimidine ring, a furan ring, a pyrazine ring, or a pyrrolidine ring.

  通式[I]所表示的新型4-(3-丁炔基)氨基嘧啶衍生物可用作杀虫剂。在通式[I]中，R1是一个单环或双环环，可能含有0至3个杂原子，例如苯基或噁唑基；R2是氢原子，-R，-OR，-C（O）OR，-C（O）NHR，-CONR2（其中R是直链或支链C1-8烷基等），羟基烷基或类似物；R3是氢原子，卤素原子，酰氧基（由（直链或支链C1-8脂肪烃基）-CO-O-等表示），或类似物；R4是氢原子，卤素原子，C1-6烷基或类似物，或者，R4和R3与嘧啶环上的碳原子一起形成噻吩环，吡咯环，咪唑环，苯环，嘧啶环，呋喃环，吡嗪环或吡咯烷环。
• AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US20210253568A1

  公开（公告）日：2021-08-19

  The invention relates to compounds of formula I inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
• US9212170B2
  申请人：——

  公开号：US9212170B2

  公开（公告）日：2015-12-15