diethyl N-2-bromo-5-methoxyphenylphosphoramidate | 1200366-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl N-2-bromo-5-methoxyphenylphosphoramidate
• 英文别名: Diethyl N-(2-bromo-5-methoxyphenyl)phosphoramidate；2-bromo-N-diethoxyphosphoryl-5-methoxyaniline
• CAS: 1200366-39-7
• 化学式: C₁₁H₁₇BrNO₄P
• 分子量: 338.138
• InChiKey: TVSLSCONYLSVSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-溴-3-硝基苯甲醚 、 亚磷酸三乙酯 以 甲苯 为溶剂， 200.0 ℃ 、2.0 MPa 条件下， 反应 0.17h， 以73%的产率得到diethyl N-2-bromo-5-methoxyphenylphosphoramidate
  参考文献：
  名称：

  Practical and reliable synthesis of dialkyl N-arylphosphoramidates with nitroarenes as substrates

  摘要：

  A new single-step transformation of readily available nitroarenes with trialkyl phosphites, which can be performed both under thermal and microwave conditions, delivers dialkyl N-arylphosphoramidates in good yields and short reaction times. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.037

文献信息

• Practical and reliable synthesis of dialkyl N-arylphosphoramidates with nitroarenes as substrates
  作者：Reda Haggam、Jürgen Conrad、Uwe Beifuss

  DOI：10.1016/j.tetlet.2009.09.037

  日期：2009.12

  A new single-step transformation of readily available nitroarenes with trialkyl phosphites, which can be performed both under thermal and microwave conditions, delivers dialkyl N-arylphosphoramidates in good yields and short reaction times. (C) 2009 Elsevier Ltd. All rights reserved.