(Z)-1-Methyl-2-phenyl-vinylamine | 109941-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-1-Methyl-2-phenyl-vinylamine
• 英文别名: 1-Phenylprop-1-en-2-amine
• CAS: 109941-85-7
• 化学式: C₉H₁₁N
• 分子量: 133.193
• InChiKey: BXYSFSIUKXZNSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (Z)-1-Methyl-2-phenyl-vinylamine 以 氘代苯 为溶剂， 生成 1-phenylpropan-2-imine
  参考文献：
  名称：

  Zielinski, W.; Mazik, M., Polish Journal of Chemistry, 1992, vol. 66, # 4, p. 661 - 668

  摘要：

  DOI：
• 作为产物：
  描述：

  1-phenylpropan-2-imine 以 氘代苯 为溶剂， 生成 (Z)-1-Methyl-2-phenyl-vinylamine
  参考文献：
  名称：

  Zielinski, W.; Mazik, M., Polish Journal of Chemistry, 1992, vol. 66, # 4, p. 661 - 668

  摘要：

  DOI：

文献信息

• Nucleophilic Rh ^I Catalyzed Selective Isomerization of Terminal Aziridines to Enamides
  作者：Yingying Tian、Doris Kunz

  DOI：10.1002/cctc.202000597

  日期：2020.9.4

  selective isomerization of various terminal N‐Boc protected aziridines to enamides was realized using the highly reactive nucleophilic rhodium catalyst C with the Lewis acid LiNTf2 as co‐catalyst under moderate conditions. The reaction proceeds smoothly with only 1 mol% catalyst loading and excellent yields were achieved. An intermediate containing an enamide with a non‐conjugated terminal C=C double bond

  使用高反应性亲核铑催化剂C和路易斯酸LiNTf 2作为助催化剂，在中等条件下实现了各种N - Boc末端保护的氮丙啶选择性异构化为酰胺。反应仅以1mol％的催化剂负载而顺利进行，并且获得了优异的产率。在反应过程中检测到一种中间体，该中间体含有一个非共轭末端C = C双键的酰胺，该中间体异构化形成热力学上较受欢迎的2-氨基苯乙烯。基于这些观察结果获得了机械的见解。
• Composition and use
  申请人：Hodge John David

  公开号：US20050008534A1

  公开（公告）日：2005-01-13

  The present invention relates to a composition comprising: (i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and (ii) an amphoteric co-polymer of the Formula (1): wherein: [A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11), wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R 1 , R 2 and R 3 are each independently H, optionally substituted C 1-20 -alkyl or optionally substituted C 3-20 -cycloalkyl; R 4 and R 5 are each independently H or C 1-4 -alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R 4 and R 5 is H.

  本发明涉及一种组合物，包括：（i）一种抗微生物剂，包括聚合物双胍，单独或与从季铵化合物、单季铵杂环胺盐、脲衍生物、氨基化合物、咪唑衍生物、腈化合物、锡化合物或配合物、异噻唑啉-3-酮、噻唑衍生物、硝基化合物、碘化合物、醛释放剂、硫醇、三嗪衍生物、氧氮杂环和其衍生物、呋喃和其衍生物、羧酸及其盐和酯、酚及其衍生物、磺酰基衍生物、酰亚胺、硫酰胺、2-巯基吡啶-N-氧化物、唑类杀菌剂、链霉素、酰胺、氨基甲酸酯、吡啶衍生物、具有活性卤素基团的化合物和有机金属化合物中选择至少一种其他微生物活性成分组合而成；和（ii）式（1）的两性共聚物：其中：[A]为式（9）；[B]为式（10）；[C]为式（12）；[D]为式（13）；且X为式（11），其中[A]，[B]，[C]和[D]可以以任何顺序出现；T为可选的取代基；L，G和Z各自独立地为可选的取代连接基；R1，R2和R3各自独立地为H，可选的取代C1-20烷基或可选的取代C3-20环烷基；R4和R5各自独立地为H或C1-4烷基；q为15至1000；p为3至50；J为可选的取代的烃基；F为酸性取代基；E为碱性取代基；m为0至350；n为1至75；v为0至100；y为1至100；b为0、1或2；s为0或1；w为1至4；并且至少R4和R5中的一个为H。
• [EN] ANTIMICROBIAL COMPOSITION CONTAINING A POLYMERIC BIGUADINE AND A COPOLYMER AND USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE POLYMERIQUE ET UN COPOLYMERE ET SON APPLICATION
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100666A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and an amphoteric co-polymer of the Formula (1); wherein [A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11),wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted Cl-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R4 and R5 is H.

  本发明涉及一种组合物，包括：一种抗微生物剂，包括聚大双胍，单独使用或与至少一种从季铵化合物、单季铵杂环胺盐、脲衍生物、氨基化合物、咪唑衍生物、腈化合物、锡化合物或配合物、异噻唑啉-3-酮、噻唑衍生物、硝基化合物、碘化合物、醛释放剂、硫醇、三嗪衍生物、噁唑烷及其衍生物、呋喃及其衍生物、羧酸及其盐和酯、苯酚及其衍生物、磺酰衍生物、亚酰胺、硫代酰胺、2-巯基吡啶-N-氧化物、咪唑类杀菌剂、斑点灵、酰胺、氨基甲酸酯、吡啶衍生物、具有活性卤素基团的化合物和有机金属化合物中选择的至少一种具有微生物活性成分；以及公式（1）的两性共聚物，其中[A]为公式（9），[B]为公式（10），[C]为公式（12），[D]为公式（13），X为公式（11），其中[A]，[B]，[C]和[D]可以以任何顺序出现；T是可选取代基；L，G和Z各自独立地是可选取代的连接基；R1，R2和R3各自独立地是H、可选取代的Cl-20-烷基或可选取代的C3-20-环烷基；R4和R5各自独立地是H或C1-4-烷基；q为15至1000；p为3至50；J为可选取代的烃基；F为酸性取代基；E为碱性取代基；m为0至350；n为1至75；v为0至100；y为1至100；b为0、1或2；s为0或1；w为1至4；并且至少有一个R4和R5为H。
• [EN] ANTIMICROBIAL COMPOSITION COMPRISING A POLYMERIC BIGUANIDE AND A COPOLYMER AND USE THEREOF<br/>[FR] COMPOSITION ANTIMICROBIENNE CONTENANT UN BIGUANIDE DE POLYMERE AINSI QU'UN COPOLYMERE ET SON UTILISATION
  申请人：ARCH UK BIOCIDES LTD

  公开号：WO2004100665A1

  公开（公告）日：2004-11-25

  The present invention relates to a composition comprising: (i) an anti-microbial agent; and (ii) a basic co-polymer of the Formula (1):) wherein [A] is of Formula (9), [B] is of Formula (10), and [D] is of Formula (12), Formula (13) X is of Formula (11), wherein [A], [B] and [D] may occur in any order; T is an optionally substituted substituent; L and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H; optionally substituted Cl-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; E is a basic substituent; q is 15 to 1000; m is 0 to 350; n is 1 to 75; y is 1 to 100; s is 0 or 1; p is 3 to 50; and provided that at least one of R4 and R5 is H and provided that R1, R2, R3, T, L and Z do not contain an acidic group which can protonate E on [D].

  本发明涉及一种组合物，包括：(i)一种抗微生物剂；以及(ii)一种公式(1)的碱性共聚物：其中[A]为公式(9)，[B]为公式(10)，[D]为公式(12)，公式(13)中X为公式(11)，其中[A]、[B]和[D]可以以任何顺序出现；T为可选取代基；L和Z各自独立地为可选取代的连接基；R1、R2和R3各自独立地为H、可选取代的Cl-20-烷基或可选取代的C3-20-环烷基；R4和R5各自独立地为H或C1-4-烷基；E为碱性取代基；q为15至1000；m为0至350；n为1至75；y为1至100；s为0或1；p为3至50；并且至少R4和R5中的一个为H，且R1、R2、R3、T、L和Z不含有可以质子化[D]上的E的酸性基团。
• Oligoribonucleotides and ribonucleases for cleaving RNA
  申请人：——

  公开号：US20030096287A1

  公开（公告）日：2003-05-22

  Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such a ribonuclease is referred to herein as a dsRNase, wherein “ds” indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.

  提供了包括寡核苷酸和寡核苷的寡聚化合物，其中包含2'-戊糖核苷酸亚序列，可以激活dsRNase。这些寡核苷酸和寡核苷可以包括取代基团，以增加与互补核酸链的结合亲和力，以及取代基团，以增加核酸酶抵抗力。这些寡聚化合物可用于诊断和其他研究目的，用于调节生物体内蛋白质的表达，以及用于诊断、检测和治疗其他易感于寡核苷酸治疗的疾病。本发明还包括哺乳动物核酸酶，即降解RNA的酶，以及这些核酸酶的底物。这样的核酸酶在本文中被称为dsRNase，其中“ds”表示RNase对某些双链RNA底物的特异性。本文所描述的dsRNases的人工底物可用于制备亲和力基质，以纯化哺乳动物核酸酶以及非降解的RNA结合蛋白。