N-phenylsulfonylcysteamine | 28196-75-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenylsulfonylcysteamine
• 英文别名: N-(2-mercaptoethyl) benzenesulfonamide；N-(2-sulfanylethyl)benzenesulfonamide
• CAS: 28196-75-0
• 化学式: C₈H₁₁NO₂S₂
• 分子量: 217.313
• InChiKey: YIFCZJACMYQVNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-phenylsulfonylcysteamine 在 sodium hydroxide 、 三乙胺 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 {4-[3-(2-Benzenesulfonylamino-ethylsulfanyl)-propyl]-phenoxy}-acetic acid
  参考文献：
  名称：

  Synthesis and evaluation of novel sulfonamide derivatives as thromboxane A2 receptor antagonists I

  摘要：

  A series of 4-[2-(arylsulfonylamino)ethylthio]phenoxyacetic acids and related compounds were synthesized. The compounds were tested for their thromboxane A2 (TXA2) receptor antagonizing effects on (15S)-15-hydroxy-11a,9a-(epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). Among the compounds synthesized, 3-{4-[2-(arylsulfonylamino)ethylthio]phenyl}propionic acids 26a-e,g showed potent TXA2 receptor antagonist activity. The most potent compound, 3-14-[2-(4-chlorophenylsulfonylamino)ethylthio]phenyl}propionic acid 26c was more than 10-fold more potent in TXA2 receptor antagonizing activity (IC50 = 1.1 X 10(-6) M) than sulotroban (BM- 1 3177) on rabbit platelets. Compound 26c was also more than 10-fold more potent in TXA2-inhibitory activity than sulotroban on rat aorta smooth muscle (pA2 7.7).

  DOI：

  10.1016/0223-5234(94)90036-1
• 作为产物：
  描述：

  bis-<2-(phenylsulfonylamino)ethyl>disulfide 在 三丁基膦 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 20.0h， 生成 N-phenylsulfonylcysteamine
  参考文献：
  名称：

  Synthesis and evaluation of novel sulfonamide derivatives as thromboxane A2 receptor antagonists I

  摘要：

  A series of 4-[2-(arylsulfonylamino)ethylthio]phenoxyacetic acids and related compounds were synthesized. The compounds were tested for their thromboxane A2 (TXA2) receptor antagonizing effects on (15S)-15-hydroxy-11a,9a-(epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). Among the compounds synthesized, 3-{4-[2-(arylsulfonylamino)ethylthio]phenyl}propionic acids 26a-e,g showed potent TXA2 receptor antagonist activity. The most potent compound, 3-14-[2-(4-chlorophenylsulfonylamino)ethylthio]phenyl}propionic acid 26c was more than 10-fold more potent in TXA2 receptor antagonizing activity (IC50 = 1.1 X 10(-6) M) than sulotroban (BM- 1 3177) on rabbit platelets. Compound 26c was also more than 10-fold more potent in TXA2-inhibitory activity than sulotroban on rat aorta smooth muscle (pA2 7.7).

  DOI：

  10.1016/0223-5234(94)90036-1

文献信息

• Photo-Responsive Microencapsulation Materials, Compositions and Methods of Use Thereof
  申请人：Stowell Michael H.B.

  公开号：US20130137625A1

  公开（公告）日：2013-05-30

  Photoactivatable prepolymers and methods of use thereof are disclosed for microencapsulation of a substantially water-insoluble material within a nonporous shell. As provided herein, the microencapsulated material is released with no more than a slow release rate. Upon exposure of the nonporous shell to light, the nonporous shell is converted into a porous shell having an increased release rate for the microencapsulated material.

  本文披露了可光活化预聚合物及其使用方法，用于微囊化在非多孔壳体内的基本不溶于水的物质。根据本文提供的，微囊化物质以不超过缓慢释放速率释放。当将非多孔壳体暴露在光线下时，非多孔壳体转化为具有增加释放速率的多孔壳体，以释放微囊化物质。
• Delivery system for meristematic tissue
  申请人：PLANT GENETICS, INC.

  公开号：EP0141373A2

  公开（公告）日：1985-05-15

  Novel methods and compositions are provided for the delivery of plant meristematic tissue to an environment for growth and development. Isolated meristematic tissue from various sources are combined with beneficial adjuvants in an encapsulating gel matrix which provides a system for the simultaneous delivery of meristematic tissue and adjuvants which can replace true botantic seed.

  本发明提供了将植物分生组织输送到生长发育环境中的新方法和组合物。从各种来源分离出来的分生组织与有益的佐剂结合在一个封装凝胶基质中，提供了一个同时输送分生组织和佐剂的系统，可以取代真正的植物种子。
• Microcapsules and microencapsulation process
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0158449A1

  公开（公告）日：1985-10-16

  Novel microcapsules are disclosed in which a liquid material which is substantially insoluble in water is enclosed within a solid permeable shell of etherified urea-formaldehyde polymer, prepared by a process which comprises: (a) providing an organic solution comprising said material and a urea-formaldehyde prepolymer in which from about 50% to about 98% of the methylol groups of said prepolymer have been etherified with a C4-C10 alcohol; (b) creating an emulsion of said organic solution in an aqueous solution comprising water and a surface-active agent, wherein said emulsion comprises discrete droplets of said organic solution dispersed in said aqueous solution; (c) causing in situ self-condensation of said urea-formaldehyde prepolymers by adding to said emulsion an acidifying agent and maintaining said emulsion at a pH of between about 0 and about 4 for a sufficient period of time to allow substantial completion of in situ condensation of said resin prepolymers to convert the liquid droplets of said organic solution to capsules consisting of solid permeable polymer shells enclosing said liquid material; and (d) heating said emulsion to a temperature between about 20°C and about 100°C to cause curing of said in situ formed polymers.

  本发明公开了一种新型微胶囊，在这种微胶囊中，基本上不溶于水的液态材料被包裹在由醚化脲醛聚合物构成的固体可渗透外壳中，其制备过程包括(a) 提供一种有机溶液，该有机溶液包括所述材料和脲醛预聚物，其中所述预聚物约 50% 至约 98% 的甲醇基团已被 C4-C10 醇醚化；(b) 在由水和表面活性剂组成的水溶液中形成所述有机溶液的乳液，其中所述乳液包括分散在所述水溶液中的所述有机溶液的离散液滴；(c) 通过向所述乳液中添加酸化剂，并将所述乳液的 pH 值保持在约 0 至约 4 之间足够长的时间，使所述树脂预聚物的原位缩合基本完成，从而将所述有机溶液的液滴转化为由固态可渗透聚合物外壳组成的胶囊，将所述液态材料包裹起来，从而使所述脲醛预聚物原位自缩合；以及 (d) 将所述乳液加热至约 20°C 至约 100°C 之间的温度，使所述原位形成的聚合物固化。
• Synergistic herbicidal compositions
  申请人：STAUFFER CHEMICAL COMPANY

  公开号：EP0149099A2

  公开（公告）日：1985-07-24

  Synergistic herbicidal activity is displayed by a compos- tion comprising the following two components: (a) an herbicidally effective amount of a thiolcarbamate of the formula in which X is hydrogen, chlorine or bromine; and R1 and R2 are independently selected from the group consisting of C1-C6 alkyl and C5-C7 cycloalkyl, and (b) an herbicidally effective amount of a dimethyl urea compound of the formula

  由以下两种成分组成的复合物具有协同除草活性：(a) 除草有效量的式硫醇氨基甲酸酯，其中 X 为氢、氯或溴；R1 和 R2 独立选自 C1-C6 烷基和 C5-C7 环烷基组成的组，以及(b) 除草有效量的式二甲基脲化合物。
• Novel sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-a)pyrimidines and compositions and methods of controlling undesired vegetation
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0150974A2

  公开（公告）日：1985-08-07

  Novel compounds, e.g., N-(5,7-dimethyl-1,2,4-triazolo-[1,5-a]pyrimidin-2-yl)-2-thiophene sulfonamide and their compositions and use in the control of weeds.

  新型化合物，如 N-(5,7-二甲基-1,2,4-三唑并-[1,5-a]嘧啶-2-基)-2-噻吩磺酰胺及其组合物和在控制杂草中的用途。