2-(4-methoxyphenyl)(piperidine-1-yl)methylphenol | 1353895-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-methoxyphenyl)(piperidine-1-yl)methylphenol
• 英文别名: 2-[4-methoxyphenyl(piperidin-1-yl)methyl]phenol；2-[(4-Methoxyphenyl)-piperidin-1-ylmethyl]phenol
• CAS: 1353895-12-1
• 化学式: C₁₉H₂₃NO₂
• 分子量: 297.397
• InChiKey: XNHYVFCPNBQEAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 4-甲氧基苯甲醛 、 苯酚 在 sulfated polyborate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.42h， 以94%的产率得到2-(4-methoxyphenyl)(piperidine-1-yl)methylphenol
  参考文献：
  名称：

  硫酸化多硼酸酯催化三组分，无溶剂合成贝蒂碱

  摘要：

  摘要在这项工作中，在溶剂化硫酸多硼酸盐催化剂存在下，由一锅三元乙醛，苯酚和吗啉的缩合反应制得的1-氨基烷基-2-苯酚/贝蒂碱的高效，温和和环保的方法描述了100°C时的无条件状态。本方法的主要优点是反应时间短，产率高，水后处理程序，成本低，稳定，可重复使用的催化剂和无溶剂的反应条件。 图形概要

  DOI：

  10.1007/s00706-018-2169-z

文献信息

• Magnetically Retrievable Nanocomposite Based on Thiosemicarbazide–Formaldehyde Resin as a Versatile Nucleophilic Scavenger
  作者：Maomin Zhen、Danfeng Zhang、Zeyu Zhang、Yanqing Peng

  DOI：10.1021/acscombsci.6b00090

  日期：2016.12.12

  retrievable nanocomposite was prepared by in situ polycondensation and entrapment of iron oxide nanoparticles. This material was found to be efficient in trapping excess electrophilic reagents such as carbonyl compounds, acid chlorides and isothiocyanates. Advantages of the new scavenger include facile preparation, high loading capacity, low cost, satisfactory swelling properties in polar solvents, and

  通过原位缩聚和包埋氧化铁纳米颗粒制备了可磁性回收的纳米复合材料。发现该材料可有效捕集过量的亲电试剂，例如羰基化合物，酰氯和异硫氰酸酯。新型清除剂的优点包括制备简便，装载量高，成本低，在极性溶剂中具有令人满意的溶胀性能以及方便的磁回收。
• Microwave-assisted nanocatalysis: A CuO NPs/rGO composite as an efficient and recyclable catalyst for the Petasis-borono–Mannich reaction
  作者：Anshu Dandia、Sarika Bansal、Ruchi Sharma、Kuldeep S. Rathore、Vijay Parewa

  DOI：10.1039/c8ra05203d

  日期：——

  CuO NPs/rGO composite was synthesized and characterized by various analytical techniques an used as a recyclable catalyst for Petasis-borono–Mannich reaction under microwave irradiation.

  CuO NPs/rGO复合材料通过各种分析技术合成和表征，并作为可回收催化剂应用于微波辐射下的Petasis-硼酸曼尼希反应。
• Cobalt ferrite nanoparticles: a magnetically separable and reusable catalyst for Petasis-Borono–Mannich reaction
  作者：Aparna M. Kulkarni、Kapil S. Pandit、Pramod V. Chavan、Uday V. Desai、Prakash P. Wadgaonkar

  DOI：10.1039/c5ra10693a

  日期：——

  Magnetically separable cobalt ferrite nanoparticles (CoFe₂O₄, NPS): an efficient catalyst in Petasis-Borono–Mannich (PBM) reaction between salicylaldehydes, sec. amines and aryl boronic acids.

  可磁分离的钴铁氧化物纳米颗粒（CoFe2O4，NPS）：在水杨醛、二级胺和芳基硼酸之间的Petasis-Borono-Mannich（PBM）反应中是一种有效的催化剂。
• Acceleration of Petasis Reactions of Salicylaldehyde Derivatives with Molecular Sieves
  作者：Xianglin Shi、Dominique Hebrault、Michael Humora、William F. Kiesman、Hairuo Peng、Tina Talreja、Zezhou Wang、Zhili Xin

  DOI：10.1021/jo202117u

  日期：2012.1.20

  Mild reaction conditions for Petasis reactions of substituted salicylaldehydes with various amines and arylboronic acids in the presence of molecular sieves were developed. Molecular sieves (MS) significantly accelerated the reaction rates and drove the reactions to high conversions. The conditions were applied to the synthesis of the core structure of BIIB042, a gamma-secretase modulator, without stereochernical erosion of a stereogenic center in the salicylaldehyde intermediate.