[6-[(4-Tert-butylphenyl)methylamino]-5-methylpyrimidin-4-yl]-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]methanone | 1232050-93-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [6-[(4-Tert-butylphenyl)methylamino]-5-methylpyrimidin-4-yl]-[4-(4-hydroxypiperidin-1-yl)piperidin-1-yl]methanone
• CAS: 1232050-93-9
• 化学式: C₂₇H₃₉N₅O₂
• 分子量: 465.639
• InChiKey: AEIISOVJMMRQFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  81.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD
  申请人：Ebel Heiner

  公开号：US20120053164A1

  公开（公告）日：2012-03-01

  The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single bond, ═CH—, —CH 2 —, —O—, —S—, and —NH—; wherein n is 1, 2 or 3; wherein Z is C or N, the other variables are as defined in the claims, as well as in form of their acid addition salts with pharmacologically acceptable acids.
• PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF CCR2 ANTAGONISTS
  申请人：EBEL Heiner

  公开号：US20140336374A1

  公开（公告）日：2014-11-13

  The present invention relates to a process for the production of novel antagonists for CCR2 (CC chemokine receptor 2) and intermediates thereof.
• US8835440B2
  申请人：——

  公开号：US8835440B2

  公开（公告）日：2014-09-16