N4-[2-(3-fluorophenyl)ethyl]-N2-[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-5,5'-bipyrimidine-2,4-diamine | 1062165-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N4-[2-(3-fluorophenyl)ethyl]-N2-[4-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-5,5'-bipyrimidine-2,4-diamine
• 英文别名: 4-N-[2-(3-fluorophenyl)ethyl]-5-pyrimidin-5-yl-2-N-[4-(1,2,4-triazol-1-ylmethyl)phenyl]pyrimidine-2,4-diamine
• CAS: 1062165-77-8
• 化学式: C₂₅H₂₂FN₉
• 分子量: 467.508
• InChiKey: GZFABBFPGFAONP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Chemical Compounds
  申请人：Deanda, JR. Felix

  公开号：US20100113445A1

  公开（公告）日：2010-05-06

  The present invention relates to dianilinopyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dianilinopyrimidine derivatives are useful in the treatment of diseases associated with inappropriate Wee1 kinase activity.

  本发明涉及二苯胺嘧啶衍生物，包含这些衍生物的组合物和药物，以及制备和使用这些化合物、组合物和药物的过程。这些二苯胺嘧啶衍生物在治疗与不适当的Wee1激酶活性相关的疾病方面是有用的。
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2008115742A1

  公开（公告）日：2008-09-25

  [EN] The present invention relates to dianilinopyrimidine derivatives, compositions and medicaments containing the same, as well as processes for the preparation and use of such compounds, compositions and medicaments. Such dianilinopyrimidine derivatives are useful in the treatment of diseases associated with inappropriate Wee1 kinase activity.
  [FR] La présente invention concerne des dérivés de dianilinopyrimidine, des compositions et médicament les contenant, ainsi que des procédés d'élaboration et d'utilisation de tels composés, compositions et médicaments. De tels dérivés de dianilinopyrimidine conviennent particulièrement au traitement d'affections associées à une activité kinase Wee1 inappropriée.