A heart valve sewing prosthesis including an intrinsically conductive polymer. The invention includes annuloplasty rings and bands, and sewing rings or cuffs for prosthetic heart valves. Some annuloplasty rings and sewing rings include fabric that is coated with an intrinsically conductive polymer. The coating can be formed over individual filaments or fibers, or on the fabric surface as a surface layer. One intrinsically conductive polymer is polypyrrole. The intrinsically conductive polymer can be doped to facilitate the intrinsic conductivity. Some devices have a polypyrrole surface layer doped with dialkyl-napthalene sulfonate. The intrinsically conductive polymer can be deposited on a fabric using in-situ polymerization of monomeric or oligomeric species, together with a dopant. Animal studies using implanted annuloplasty rings having an intrinsically conductive polymer coating have demonstrated a substantial reduction in pannus formation and inflammatory response.
一种包括本征导电聚合物的心脏瓣膜缝合假体。本发明包括用于人工心脏瓣膜的瓣环和瓣带以及缝合环或袖口。一些瓣环和缝合环包括涂有本征导电聚合物的织物。涂层可以形成在单根细丝或纤维上,也可以作为表层形成在织物表面。一种本征导电聚合物是聚
吡咯。本征导电聚合物可以掺杂,以提高本征导电性。有些设备的聚
吡咯表层掺有二烷基
萘磺酸盐。本征导电聚合物可通过单体或低聚物与掺杂剂的原位聚合沉积在织物上。使用具有本征导电聚合物涂层的植入环形成形环进行的动物实验表明,这种环形成形环可大大减少脓肿的形成和炎症反应。