3-amino-5-nitro-benzophenone | 372093-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-5-nitro-benzophenone
• 英文别名: 3-Amino-5-nitro-benzophenon；3-Amino-5-nitrobenzophenone；(3-amino-5-nitrophenyl)-phenylmethanone
• CAS: 372093-09-9
• 化学式: C₁₃H₁₀N₂O₃
• 分子量: 242.234
• InChiKey: KETSAQNIVKYOKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-amino-5-nitro-benzophenone 、 甲基磺酰氯 在 吡啶 作用下， 反应 4.0h， 生成 N-(3-acetyl-5-nitrophenyl)methanesulfonamide
  参考文献：
  名称：

  BICYCLIC COMPOUND

  摘要：

  公开号：

  EP1447400B1
• 作为产物：
  描述：

  3,5-二硝基二苯甲酮 在 硫化氢 、 氨 作用下， 生成 3-amino-5-nitro-benzophenone
  参考文献：
  名称：

  Waters, Journal of the Chemical Society, 1929, p. 2108

  摘要：

  DOI：

文献信息

• Novel bicyclic compounds
  申请人：——

  公开号：US20030191174A1

  公开（公告）日：2003-10-09

  Compounds of the general formula (I): 1 or a salt thereof, wherein R 1 is hydrogen, hydroxyl or halogen; R 2 is NHSO 2 CH 3 , SO 2 NHCH 3 or the like; R 5 and R 6 each independently is hydrogen, C 1-6 alkyl, optionally substituted phenyl or optionally substituted benzyl; X is NH, sulfur, oxygen or methylene; Y is oxygen, NR 7 , sulfur, methylene or a bond; and * represents an asymmetric carbon atom. The compounds are useful as a medicine for treating or preventing diabetes, obesity, hyperlipidemia, digestive diseases, depression or urinary disturbances.

  通式（I）的化合物：1或其盐，其中R1是氢、羟基或卤素；R2是NHSO2CH3、SO2NHCH3或类似物；R5和R6各自独立地是氢、C1-6烷基、可选择取代的苯基或可选择取代的苄基；X是NH、硫、氧或亚甲基；Y是氧、NR7、硫、亚甲基或键；*代表一个不对称的碳原子。这些化合物可用作治疗或预防糖尿病、肥胖症、高脂血症、消化系统疾病、抑郁症或尿路紊乱的药物。
• Substituted benzoylhaloalkanesulfonanilides
  申请人：RIKER LABORATORIES, INC.

  公开号：US03725451A1

  公开（公告）日：1973-04-03

  Benzoylhaloalkanesulfonanilides having ring substituents selected from amino, nitro, carboxyl, mercapto, phenylsulfinyl, phenylsulfonyl, lower alkylsulfonamido, lower alkanoylamino, lower alkylthio, lower alkanoyloxy, lower alkylsulfamoyl, lower alkylsulfonoxy and lower haloalkylsulfonoxy. These compounds and salts thereof are active anti-inflammatory agents and some also have anti-pyretic and analgesic activity.

  选自氨基、硝基、羧基、巯基、苯基亚磺酰基、苯基磺酰基、低碳烷基磺酰胺基、低碳酰胺基、低碳硫基、低碳酰氧基、低碳烷基磺酰氨基、低碳烷基磺酸酯氧基和低碳卤代烷基磺酸酯氧基的苯甲酰卤代烷烷基磺酰苯胺类化合物及其盐是活性抗炎药物，其中一些还具有抗热和镇痛作用。
• Bicyclic compound
  申请人：Miyoshi Shiro

  公开号：US20050020602A1

  公开（公告）日：2005-01-27

  A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. R 2 represents NHSO 2 R 3 , etc., provided that R 3 represents C 1-6 alkyl, etc. R 5 represents hydrogen, etc. R 6 and R 7 may be the same or different and each independently represents hydrogen, etc. X represents oxygen, etc. Y represents oxygen, etc. Z 1 to Z 6 each represents carbon, etc. n is an integer of 0 to 6 and ast1 indicates that the carbon atom is asymmetric, and *2, in the case where R 5 is not hydrogen, indicates that the carbon atom is asymmetric or a salt of the compound.

  化合物的通式为I：I，其中R1代表氢等，R2代表NHSO2R3等，但R3代表C1-6烷基等，R5代表氢等，R6和R7可以相同也可以不同，且各自独立地代表氢等，X代表氧等，Y代表氧等，Z1至Z6各自代表碳等，n为0至6的整数，ast1表示碳原子是不对称的，*2表示当R5不是氢时，碳原子是不对称的或化合物的盐。
• Indole compounds as B3 androceptor agonist
  申请人：Miyoshi Shiro

  公开号：US20080076815A1

  公开（公告）日：2008-03-27

  Compounds of the general formula (I): or a salt thereof, wherein R 1 is a hydrogen atom or the like; R 2 is NHSO 2 R 3 or the like; R 3 is a (C 1 -C 6 )alkyl group or the like; R 5 is a hydrogen atom or the like; R 6 and R 7 may be the same or different and are each independently a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Z 1 to Z 6 are a carbon atom or the like; n is an integer of 0 to 6; *1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when R 5 is other than a hydrogen atom.

  通式(I)的化合物或其盐，其中R1是氢原子或类似物；R2是NHSO2R3或类似物；R3是(C1-C6)烷基或类似物；R5是氢原子或类似物；R6和R7可以相同或不同，且各自独立地是氢原子或类似物；X是氧原子或类似物；Y是氧原子或类似物；Z1至Z6是碳原子或类似物；n是0到6的整数；*1是不对称碳原子；当R5不是氢原子时，*2是不对称碳原子。
• Indazole compounds as β3 adrenoceptor agonist
  申请人：Asahi Kasei Pharma Corporation

  公开号：US07271190B2

  公开（公告）日：2007-09-18

  A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. R2 represents NHSO2R3, etc., provided that R3 represents C1-6 alkyl, etc. R5 represents hydrogen, etc. R6 and R7 may be the same or different and each independently represents hydrogen, etc. X represents oxygen, etc. Y represents oxygen, etc. Z1 to Z6 each represents carbon, etc. n is an integer of 0 to 6 and ast1 indicates that the carbon atom is asymmetric, and *2, in the case where R5 is not hydrogen, indicates that the carbon atom is asymmetric or a salt of the compound.

  化合物由一般式I表示：其中R1代表氢等，R2代表NHSO2R3等，但要求R3代表C1-6烷基等，R5代表氢等，R6和R7可以相同也可以不同，分别独立地代表氢等，X代表氧等，Y代表氧等，Z1至Z6各自代表碳等，n是0至6的整数，ast1表示该碳原子是不对称的，而*2，在R5不是氢的情况下，表示该碳原子是不对称的或该化合物的盐。