Pt(2-vinylpyridine-H)(CH₃)(DMSO) | 1604677-54-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pt(2-vinylpyridine-H)(CH₃)(DMSO)
• CAS: 1604677-54-4
• 化学式: C₁₀H₁₅NOPtS
• 分子量: 392.381
• InChiKey: VFFGHWPWNCTVSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  盐酸 、 Pt(2-vinylpyridine-H)(CH₃)(DMSO) 以 水 、 丙酮 为溶剂， 反应 1.0h， 以90%的产率得到Pt(2-vinylpyridine-H)(Cl)(DMSO)
  参考文献：
  名称：

  Cyclometalated Complexes of Platinum(II) with 2‐Vinylpyridine

  摘要：

  AbstractThe electron‐rich platinum(II) derivatives [Pt(R)2(DMSO)2] (R = Me, Ph) react with 2‐vinylpyridine (L) to give the cyclometalated complexes [Pt(L–H)(R)(DMSO)] through C–H bond activation. Cyclometalation also occurs with [Pt(Me)(Cl)(DMSO)2]. From the starting compounds, a series of cyclometalated complexes was obtained and characterised by analytical and spectroscopic methods. The molecular structures of [Pt(L–H)(Me)(PPh3)] and [Pt(L–H)(Ph)(PCy3)] were solved by X‐ray diffraction analysis, and the results unambiguously demonstrate cyclometalation of 2‐vinylpyridine. The five‐membered cyclometalated ring is particularly stable, likely due to partial electronic delocalisation.

  DOI：

  10.1002/ejic.201400052
• 作为产物：
  描述：

  2-乙烯基吡啶 、 cis-[Pt(CH3)2(dimethyl sulfoxide)2] 以 甲苯 为溶剂， 反应 2.0h， 以85%的产率得到Pt(2-vinylpyridine-H)(CH₃)(DMSO)
  参考文献：
  名称：

  Cyclometalated Complexes of Platinum(II) with 2‐Vinylpyridine

  摘要：

  AbstractThe electron‐rich platinum(II) derivatives [Pt(R)2(DMSO)2] (R = Me, Ph) react with 2‐vinylpyridine (L) to give the cyclometalated complexes [Pt(L–H)(R)(DMSO)] through C–H bond activation. Cyclometalation also occurs with [Pt(Me)(Cl)(DMSO)2]. From the starting compounds, a series of cyclometalated complexes was obtained and characterised by analytical and spectroscopic methods. The molecular structures of [Pt(L–H)(Me)(PPh3)] and [Pt(L–H)(Ph)(PCy3)] were solved by X‐ray diffraction analysis, and the results unambiguously demonstrate cyclometalation of 2‐vinylpyridine. The five‐membered cyclometalated ring is particularly stable, likely due to partial electronic delocalisation.

  DOI：

  10.1002/ejic.201400052

文献信息

• Cycloplatinated(II) complex bearing 2-vinylpyridine and monodentate phosphine ligands: Optical properties and kinetic study
  作者：Maryam Niazi、Hamid R. Shahsavari

  DOI：10.1016/j.jorganchem.2015.12.005

  日期：2016.2

  solid state and solution at room temperature and at 77 K. This complex displays an intense phosphorescence emission (with a significantly long lifetime) which is originated from mixed 3ILCT/3MLCT excited state. Additionally, complex 1 undergoes oxidative addition with alkyl halide (MeI) bearing [PtMe2I(Vpy)(PPh2Me)], 2, after 2 h. Kinetic studies suggest that the latter reaction (oxidative addition)

  2- vinylpyridinate络合物[PTME（VPY）（DMSO）〕，Ç，被成功地从二聚铂（II）配合物制备的顺式，顺式- [我2的PT（μ -SMe 2）2 PTME 2 ]，乙，在DMSO和2-乙烯基吡啶配体的存在 在复合物中的DMSO分子Ç可以通过甲基二（PPH容易地取代的2 Me）时，允许合成[PTME（VPY）（PPH 2 Me）的]，1，已被充分表征光谱。综合大楼1在室温和77 K下在固态和溶液中均呈发射态。这种络合物显示出强烈的磷光发射（具有相当长的寿命），这是由3 ILCT / 3 MLCT混合激发态引起的。此外，复合物1在2小时后与带有[PTMe 2 I（VPy）（PPh 2 Me）] 2的烷基卤（MeI）进行氧化加成。动力学研究表明，后者的反应（氧化加成）是通过经典的S N 2机理进行的。测量了在不同温度下的氧化加成反应速率，并得出了较高的负ΔS ＃获得支持所提
• Cycloplatinated(<scp>ii</scp>) complexes bearing 1,1′-bis(diphenylphosphino)ferrocene ligand: biological evaluation and molecular docking studies
  作者：Masood Fereidoonnezhad、Hamid R. Shahsavari、Sedigheh Abedanzadeh、Behnoosh Behchenari、Mojdeh Hossein-Abadi、Zahra Faghih、M. Hassan Beyzavi

  DOI：10.1039/c7nj04183g

  日期：——

  In this study, the cytotoxic activities of structurally related cycloplatinated(II) complexes containing chelating and bridging 1,1′-bis(diphenylphosphino)ferrocene (dppf) ligand derived from a wide range of C^N cyclometalating ligands (vpy = deprotonated 2-vinylpyridine, bzq = deprotonated benzo[h]quinoline, bpy = deprotonated 2,2′-bipyridine, bpyO = deprotonated 2,2′-bipyridine N-oxide, and ppy =

  在这项研究中，结构相关的环铂（II）配合物的螯合和桥连的1,1'-双（二苯基膦基）二茂铁（dppf）配体具有广泛的C ^ N环金属配体（vpy =去质子化的2-针对人肺评估了乙烯基吡啶，bzq =去质子化的苯并[ h ]喹啉，bpy =去质子化的2,2'-联吡啶，bpyO =去质子化的2,2'-联吡啶N-氧化物，和ppy =去质子化的2-苯基吡啶（A549） ），卵巢癌（SKOV3）和乳腺癌（MCF-7）细胞系。最具细胞毒性的化合物2a，2c和2d通过诱导A549，SKOV3和MCF-7癌细胞系的凋亡而有效地产生细胞死亡。另外，进行分子对接模拟以确定特异性结合模式和与DNA结合的方向。根据生物学评估的结果，含dppf的环铂（II）配合物表现出与DNA的强相互作用以及对人癌细胞系的高细胞毒性和凋亡诱导活性。本研究表明，新的基于铂的复合物的精确合理设计将导致制备潜在的抗癌药物，从而诱导容易的细胞凋亡。