ioforminol | 1095110-48-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ioforminol
• 英文别名: 5,5'-(2-hydroxypropane-1,3-diyl)bis(formylazanediyl)bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)；5-[[3-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-N-formyl-2,4,6-triiodoanilino]-2-hydroxypropyl]-formylamino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
• CAS: 1095110-48-7
• 化学式: C₃₃H₄₀I₆N₆O₁₅
• 分子量: 1522.14
• InChiKey: BFVVDRUCXCIALU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  60
• 可旋转键数：
  22
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  339
• 氢给体数：
  13
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  5-氨基-2,4,6-三碘-N,N’-二(2,3-二羟基丙基)-1,3-苯二甲酰胺 在 硼酸 、 乙酸酐 、 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 9.25h， 生成 ioforminol
  参考文献：
  名称：

  JP5830589

  摘要：

  公开号：

文献信息

• DESALINATION OF A COMPOSITION COMPRISING A CONTRAST AGENT
  申请人：Birkeland Aslaug

  公开号：US20130277221A1

  公开（公告）日：2013-10-24

  The invention relates to industrial preparation of contrast agents, and further to an improved process for the purification of contrast agents. In particular, it relates to a process for reducing the salt content of compositions comprising an MR contrast agent or an X-ray contrast agent, such as a non-ionic iodinated monomeric compound or a non-ionic iodinated dimeric compound.

  这项发明涉及对造影剂的工业制备，进一步涉及改进的造影剂纯化过程。具体来说，它涉及一种用于减少含有MR造影剂或X射线造影剂的成分的盐含量的过程，例如非离子碘单体化合物或非离子碘二聚体化合物。
• PREPARATION OF INTERMEDIATES OF X-RAY CONTRAST AGENTS
  申请人：GE Healthcare AS

  公开号：US20150274645A1

  公开（公告）日：2015-10-01

  The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. It particularly relates to an improved process for preparation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A) or N,N′-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodoisophthalamide (Compound C), which are intermediates in the industrial preparation of non-ionic X-ray contrast agents. More particularly the invention provides a process for deacylation of the acylated hydroxyl groups of an intermediate compound of Compound A and Compound C.

  本发明涉及一种制备碘化X射线造影剂的过程，特别涉及其中的关键中间体。特别地，它涉及一种改进的制备5-乙酰氨基-N,N′-双(2,3-二羟丙基)-2,4,6-三碘异酞酰胺(化合物A)或N,N′-双(2,3-二羟丙基)-5-甲酰胺基-2,4,6-三碘异酞酰胺(化合物C)的方法，它们是非离子X射线造影剂的工业制备中间体。更具体地，本发明提供了一种去酰基化化合物A和化合物C的中间体羟基的过程。
• CONTRAST AGENTS
  申请人：GE HEALTHCARE AS

  公开号：US20150191422A1

  公开（公告）日：2015-07-09

  The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R 3 )—R wherein X denoted an optionally substituted alkylene group, R 3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.

  本发明涉及一类化合物以及含有这些化合物的诊断组合物，其中这些化合物是含碘化合物。更具体地，这些含碘化合物是化学化合物，包含两个连接的碘化苯基团，其通式为R—N(CHO)—X—N(R3)—R，其中X表示可选的取代烷基基团，R3表示氢原子或酰基功能基团，每个R表示三碘苯基残基，进一步取代亲水性基团。本发明还涉及将这种诊断组合物用作对比剂，在诊断成像中特别是X射线成像中使用，并涉及含有这些化合物的对比介质。
• Endotoxin removal in contrast media
  申请人：GE Healthcare AS

  公开号：EP2286887A1

  公开（公告）日：2011-02-23

  The present invention relates to the purification of contrast media, and more specifically to the removal of endotoxins in such contrast media, wherein the media are contacted with an anion exchange membrane.

  本发明涉及造影剂的净化，更具体地说，涉及去除造影剂中的内毒素，其中造影剂与阴离子交换膜接触。
• X-ray imaging contrast media with low iodine concentration and X-ray imaging process
  申请人：GE HEALTHCARE AS

  公开号：US10004816B2

  公开（公告）日：2018-06-26

  The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.

  本发明涉及 X 射线检查和改善检查过程中的病人安全。更具体地说，本发明涉及具有低浓度碘和优化量电解质的 X 射线诊断组合物。本发明还涉及 X 射线检查方法，其中给人体使用含有低浓度碘的 X 射线诊断组合物，并用辐射剂量照射。