9-(2,3-dimethoxy-propyl)-9H-purin-6-ylamine | 69895-56-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2,3-dimethoxy-propyl)-9H-purin-6-ylamine
• 英文别名: 9-[(RS)-2,3-Dimethoxypropyl]adenine；9-(2,3-dimethoxypropyl)purin-6-amine
• CAS: 69895-56-3
• 化学式: C₁₀H₁₅N₅O₂
• 分子量: 237.261
• InChiKey: LKJGJYJCYBQOKU-UHFFFAOYSA-N

物化性质

• 熔点：
  184-185 °C(Solv: ethanol (64-17-5))
• 沸点：
  445.7±55.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  [(2S)-2,3-dimethoxypropyl] 4-methylbenzenesulfonate 、 腺嘌呤 以60%的产率得到
  参考文献：
  名称：

  HOLY A., COLLECT. CZECH. CHEM. COMMUN., 1978, 43, NO 12, 3444-3465

  摘要：

  DOI：

文献信息

• S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
  申请人：Aligos Therapeutics, Inc.

  公开号：US20210189392A1

  公开（公告）日：2021-06-24

  Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC 50 that is less than 100 nM.
• HBV BINDING OLIGONUCLEOTIDES AND METHODS OF USE
  申请人：Aligos Therapeutics, Inc.

  公开号：US20220056451A1

  公开（公告）日：2022-02-24

  Oligonucleotides that target hepatitis B virus (HBV) viral sequences, such as rcDNA, cccDNA, and HBV transcripts, are described herein. In addition, compositions and kits comprising such oligonucleotides are further described. Further disclosed herein are uses of such oligonucleotides and compositions to reduce rcDNA to cccDNA conversion, reduce cccDNA levels, and/or treat an HBV infection.