(4-((1H-indazol-6-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(naphthalen-1-yl)methanone | 1313039-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-((1H-indazol-6-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(naphthalen-1-yl)methanone
• 英文别名: [4-(1H-indazol-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-naphthalen-1-ylmethanone
• CAS: 1313039-21-2
• 化学式: C₂₄H₁₆N₆O
• 分子量: 404.431
• InChiKey: UOLGUWUNBWDLCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Substituted Pyrrolo-Aminopyrimidine Compounds
  申请人：Liu Yanbin

  公开号：US20110160203A1

  公开（公告）日：2011-06-30

  The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及替代吡咯-氨基嘧啶化合物及合成这些化合物的方法。本发明还涉及含有替代吡咯-氨基嘧啶化合物的药物组合物，以及通过向需要的受试者投与这些化合物和药物组合物来治疗细胞增殖性疾病，如癌症的方法。
• SUBSTITUTED INDAZOL-PYRROLOPYRIMIDINES USEFUL IN THE TREATMENT OF HYPERFOLIFERATIVE DISORDERS
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150218173A1

  公开（公告）日：2015-08-06

  The present invention relates to substituted indazol-pyrrolopyrimidine compounds of general formula I: in which R 1a , R 1b , R 1c , R 1d , R 2a are as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及通式I的取代的吲哚嘧啶-吡咯并嘧啶化合物：其中R1a，R1b，R1c，R1d，R2a如本文所述和定义，以及制备该化合物的方法，用于制备该化合物的中间化合物，包含该化合物的药物组合物和组合物，以及使用该化合物制造用于治疗或预防疾病的药物组合物，特别是用作唯一的活性成分或与其他活性成分组合使用，这些疾病特别是增生性和/或血管生成障碍。
• US8580803B2
  申请人：——

  公开号：US8580803B2

  公开（公告）日：2013-11-12
• [EN] SUBSTITUTED PYRROLO-AMINOPYRIMIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRROLOAMINOPYRIMIDINE SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2011082273A2

  公开（公告）日：2011-07-07

  The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.