2,2'-diphenyl-1(3)H,1'(3')H-5,5'-methanediyl-bis-benzoimidazole | 56317-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,2'-diphenyl-1(3)H,1'(3')H-5,5'-methanediyl-bis-benzoimidazole
• 英文别名: 2-phenyl-6-[(2-phenyl-3H-benzimidazol-5-yl)methyl]-1H-benzimidazole
• CAS: 56317-37-4
• 化学式: C₂₇H₂₀N₄
• 分子量: 400.483
• InChiKey: OYGPKCFMUGLXTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-[4-[(4-benzamido-3-nitrophenyl)methyl]-2-nitrophenyl]benzamide 以73%的产率得到
  参考文献：
  名称：

  KORSHAK V. V.; GVERDTSITELI I. M.; KIPIANI L. G.; TABIDZE R. S.; LEKAS T.+, IZV. AN GRUZSSR. CEP. XIM., 1979, 5, HO 3, 210-216

  摘要：

  DOI：

文献信息

• Anti-fungal inhibitors
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US11246857B2

  公开（公告）日：2022-02-15

  Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans, or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.

  本文描述了通过向受试者施用一种或多种本发明化合物来治疗或预防真菌感染的方法。例如，本发明的方法可治疗或预防新变形真菌、加特氏真菌、增殖真菌、白僵菌或其组合的真菌感染。本发明的化合物可与其他制剂如抗真菌制剂一起施用给受试者。
• NOVEL ANTI-FUNGAL INHIBITORS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20210077464A1

  公开（公告）日：2021-03-18

  Described herein are methods of treating or preventing a fungal infection by administering one or more compounds of the present invention to a subject. The methods of the present invention treat or prevent a fungal infection of C. neoformans, C. gattii, L. prolificans, C. albicans , or a combination thereof, as examples. The compounds of the present invention may be administered to a subject with other agents such as antifungal agents.