tert-butyl (2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl)carbamate | 1187020-26-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: tert-butyl (2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl)carbamate
• 英文别名: tert-Butyl (2,4-dioxo-1,3-diazaspiro[4.5]decan-8-yl)carbamate；tert-butyl N-(2,4-dioxo-1,3-diazaspiro[4.5]decan-8-yl)carbamate
• CAS: 1187020-26-3
• 化学式: C₁₃H₂₁N₃O₄
• 分子量: 283.327
• InChiKey: XIKKUPHZTQJBCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  96.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl)carbamate 在 盐酸 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 反应 10.0h， 生成 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione
  参考文献：
  名称：

  Synthesis and structure–activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents

  摘要：

  A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives 7-36 was synthesized and their pharmacological activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds 24, 27, and 34 showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.

  DOI：

  10.1007/s00044-012-0265-x
• 作为产物：
  描述：

  trans-4-hydroxycyclohexylamine hydrochloride 在 sodium cyanide 、 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 66.0h， 生成 tert-butyl (2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl)carbamate
  参考文献：
  名称：

  Synthesis and structure–activity relationship studies on novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives as anticonvulsant agents

  摘要：

  A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives 7-36 was synthesized and their pharmacological activity was determined with the objective to better understand their structure-activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) test and their neurotoxic effects were determined by rotarod test. Majority of the compounds were active in MES tests. Compounds 24, 27, and 34 showed a significant and protective effect on seizure, when compared with standard drug phenytoin. The compounds having amide bond showed moderate protective effect on MES induced seizures compared to sulfonamide.

  DOI：

  10.1007/s00044-012-0265-x

文献信息

• [EN] PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF<br/>[FR] DÉRIVÉ DE PYRAZOLE PYRIMIDINE ET UTILISATIONS DE CELUI-CI
  申请人：YISSUM RES DEV CO

  公开号：WO2017021969A1

  公开（公告）日：2017-02-09

  The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or lnterleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.

  本发明提供了抑制酪蛋白激酶I（CKI）和/或白细胞介素-1受体相关激酶1（IRAK1）的吡唑嘧啶衍生物，以及它们的制备方法、包含它们的组合物和在治疗恶性疾病和紊乱的方法中的用途，以及治疗炎症性疾病和紊乱的方法。
• Pyrazole pyrimidine derivative and uses thereof
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem LTD

  公开号：US10376511B2

  公开（公告）日：2019-08-13

  The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.

  本发明提供了抑制酪蛋白激酶 I（CKI）和/或白细胞介素-1 受体相关激酶 1（IRAKI）的吡唑嘧啶衍生物及其制造方法、包含它们的组合物以及它们在治疗恶性疾病和紊乱以及治疗炎症性疾病和紊乱的方法中的用途。
• PYRAZOLE PYRIMIDINE DERIVATIVE AND USES THEREOF
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem LTD.

  公开号：US20180214447A1

  公开（公告）日：2018-08-02

  The present invention provides pyrazole pyrimidine derivatives which inhibit Casein kinase I (CKI) and/or Interleukin-1 receptor-associated kinase 1 (IRAKI) and methods of their manufacture, compositions comprising them and uses thereof in methods of treating malignant disease and disorders and methods for treating inflammatory diseases and disorders.