5-((2-(trifluoromethyl)phenyl)diazenyl)pyrimidine-4,6-diol | 1379977-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-((2-(trifluoromethyl)phenyl)diazenyl)pyrimidine-4,6-diol
• CAS: 1379977-41-9
• 化学式: C₁₁H₇F₃N₄O₂
• 分子量: 284.197
• InChiKey: LMURRTGGCISJFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90.96
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  4,6-二羟基嘧啶 、 邻氨基三氟甲苯 在 溶剂黄146 、 丙酸 、 硫酸 、 sodium nitrite 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.5h， 以85%的产率得到5-((2-(trifluoromethyl)phenyl)diazenyl)pyrimidine-4,6-diol
  参考文献：
  名称：

  Synthesis, spectral characterization and antimicrobial activity of some new azo dyes derived from 4,6-dihydroxypyrimidine

  摘要：

  A number of new azo disperse dyes were synthesized by coupling 4,6-dihydroxypyrimidine with diazonium salts derived from 4-methoxy aniline, N-(4-amino phenyl) acetamide. 3- and 4-methyl aniline, 2-trifiuoromethyl aniline. 4-flouoroaniline, 4-cyanoaniline, 4-amino acetophenone, 4-nitroaniline, 2-bromo-4-methyl aniline and 4-amino azobenzene. Spectroscopic data of these dyes, dissolved in six polar solvents, were measured. The effects of acid, base, temperature and concentration on the visible absorption spectra of the dyes are also reported. The structures of all compounds were confirmed by FT-IR spectra, electronic absorption spectra in UV and visible regions, H-1 NMR, mass spectroscopy and elemental analysis. In addition, the antimicrobial activity of the dyes was examined in detail. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molliq.2012.03.003