N-(4-chloro-3-trifluoromethylphenyl)-N'-(2,6-difluorobenzoyl)-urea | 62513-70-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chloro-3-trifluoromethylphenyl)-N'-(2,6-difluorobenzoyl)-urea
• 英文别名: US10322118, Urea-Based Scaffold Entry 6；N-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl]-2,6-difluorobenzamide
• CAS: 62513-70-6
• 化学式: C₁₅H₈ClF₅N₂O₂
• 分子量: 378.686
• InChiKey: AIZKBPNPUPCRTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,6-二氟苯甲酰异氰酸酯 、 2-氯-5-氨基三氟甲苯 在 甲苯 、 petroleum ether 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以18.0 g (95% of theory) of N-(4-chloro-3-trifluoromethylphenyl)-N'-(2,6-difluorobenzoyl)-urea of melting point 220° C were obtained的产率得到N-(4-chloro-3-trifluoromethylphenyl)-N'-(2,6-difluorobenzoyl)-urea
  参考文献：
  名称：

  Insecticidal N-(substituted phenyl)-N'-benzoyl ureas

  摘要：

  具有杀虫性质的式子为##STR1##的N-(取代苯基)-N'-苯甲酰基脲，其中R为氯或氟，R'为氯、氟或氢，R"为氟、氯或溴。

  公开号：

  US04085226A1

文献信息

• Compounds and methods for inhibiting Cif virulence factor
  申请人：Trustees of Dartmouth College

  公开号：US10322118B2

  公开（公告）日：2019-06-18

  The present invention provides a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.

  本发明提供了一种用于鉴定铜绿假单胞菌 CFTR 抑制因子抑制剂的筛选试验，以及用于改善或治疗呼吸道疾病（如囊性纤维化）或继发感染的组合物和方法。
• COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR
  申请人：Trustees of Dartmouth College

  公开号：US20150045389A1

  公开（公告）日：2015-02-12

  The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.
• US4085226A
  申请人：——

  公开号：US4085226A

  公开（公告）日：1978-04-18
• [EN] COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR L'INHIBITION DU FACTEUR DE VIRULENCE CIF
  申请人：DARTMOUTH COLLEGE

  公开号：WO2013155047A2

  公开（公告）日：2013-10-17

  The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.