4-[3-{2-chlorobenzimidazol-1-yl}prop-1-ynyl]benzaldehyde | 868362-92-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-[3-{2-chlorobenzimidazol-1-yl}prop-1-ynyl]benzaldehyde
• 英文别名: 4-[3-(2-Chlorobenzimidazol-1-yl)prop-1-ynyl]benzaldehyde
• CAS: 868362-92-9
• 化学式: C₁₇H₁₁ClN₂O
• 分子量: 294.74
• InChiKey: TZKCPOTYXVJOFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ANTIDIABETIC AGENTS<br/>[FR] AGENTS ANTIDIABETIQUES
  申请人：RANBAXY LAB LTD

  公开号：WO2005100331A2

  公开（公告）日：2005-10-27

  The present invention relates to alkynyl derivatives, which have PPAR agonist activity and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used for the treatment of diabetes and diabetes-associated complications, for the treatment of diseases and conditions in which insulin resistance is the central pathophysiological mechanism, for the treatment of diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndorme, hypertensive nephrosclerosis, polycystic ovarian syndrome, eating disorders, psoriasis, obesity, for improving cognitive functions in dementia and as aldose reductase inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diabetes mellitus and the diseases and conditions mediated through insulin resistance are provided.