AAAAAAK | 136803-63-9

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: AAAAAAK
• 英文别名: H-Ala-Ala-Ala-Ala-Ala-Ala-Lys-OH；(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]hexanoic acid
• CAS: 136803-63-9
• 化学式: C₂₄H₄₄N₈O₈
• 分子量: 572.662
• InChiKey: FALOOLNTAZZHFH-TYXVVTFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  264
• 氢给体数：
  9
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  Fmoc-L-丙氨酸 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 AAAAAAK
  参考文献：
  名称：

  Antibacterial Activities of Short Designer Peptides: a Link between Propensity for Nanostructuring and Capacity for Membrane Destabilization

  摘要：

  Amphiphilic peptides A(3)K, A(6)K and A(9)K displayed an increasing propensity for nanoaggregation with increasing the size of hydrophobic alanine moiety, and the size and shape of the aggregates showed a steady transition from loose peptide stacks formed by A(3)K long nanofibers by A(6)K, to short and narrow nanorods by A(9)K This size and shape transition was broadly consistent with the trend predicted from interfacial packing and curvature change if these peptide surfactants were treated as conventional surfactants The antibacterial capacity, defined by the killing of percentage of bacteria in a given time and peptide concentration, showed a strong correlation to peptide hydrophobicity, evident from both microscopic and fluorescence imaging studies For A(9)K, the power for membrane permeation and bacterial clustering intensified with peptide concentration and incubation time These results thus depict it positive correlation between the propensity for self-assembly of the peptides, their membrane penetration power, and bactericidal capacity Although the exposure of A(9)K to a preformed DPPC membrane bilayer showed little structural disturbance. the same treatment to the preformed DPPG membrane bilayer led to substantial disruption of model membrane structure, a trend entirely consistent with the high selectivity observed from membrane hemolytic studies.

  DOI：

  10.1021/bm901130u

文献信息

• METHODS FOR COSMETIC SKIN REMODELING
  申请人：ELC Management LLC

  公开号：US20210106506A1

  公开（公告）日：2021-04-15

  The methods described herein provide self-assembling macromolecular networks within the human skin. The methods provide instant and accumulation-based physical properties within the skin, causing cosmetic benefits including, bulking/plumping, filling, strengthening, smoothing, firming, and lifting, as well as enhancing the optical properties, radiance and other cosmetic appearance characteristics of the skin. The disclosure also provides a method of re-structuring the skin without cellular biogenesis by effecting macrostructures within the skin. The method comprising effectuating self-assembly within the skin layers by topically applying a composition comprising at least one self-assembly material to form functional macrostructures within the skin and effectuating self-assembly of the at least one self-assembly material in vivo while substantially preventing self-assembly prior to the topical application or treatment.