3,6,8-Tris(3,5-dimethylphenyl)quinoline | 1447765-85-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 3,6,8-Tris(3,5-dimethylphenyl)quinoline
• 英文别名: 3,6,8-tris(3,5-dimethylphenyl)quinoline
• CAS: 1447765-85-6
• 化学式: C₃₃H₃₁N
• 分子量: 441.616
• InChiKey: YGVXIXXCZNPDHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,2,3,4-四氢喹啉 在 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 偶氮二异丁腈 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 苯 为溶剂， 反应 12.0h， 生成 3,6,8-Tris(3,5-dimethylphenyl)quinoline
  参考文献：
  名称：

  Synthesis and Suzuki-Miyaura Reactions of 3,6,8-Tribromoquinoline: A Structural Revision

  摘要：

  It was earlier reported that the bromination of 1,2,3,4-tetrahydroquinoline with NBS would give 4,6,8-tribromoquinoline. This reaction was reinvestigated, and the structure was assigned to be 3,6,8-tribromoquinoline. Suzuki-Miyaura cross-coupling reactions of this molecule allowed for a convenient synthesis of 3,6,8-triarylquinolines.

  DOI：

  10.1055/s-0032-1316904

文献信息

• Synthesis and Suzuki-Miyaura Reactions of 3,6,8-Tribromoquinoline: A Structural Revision
  作者：Peter Langer、Omer Akrawi、Hamid Mohammed

  DOI：10.1055/s-0032-1316904

  日期：——

  It was earlier reported that the bromination of 1,2,3,4-tetrahydroquinoline with NBS would give 4,6,8-tribromoquinoline. This reaction was reinvestigated, and the structure was assigned to be 3,6,8-tribromoquinoline. Suzuki-Miyaura cross-coupling reactions of this molecule allowed for a convenient synthesis of 3,6,8-triarylquinolines.