3-((1R,3R,5S)-Bicyclo[3.2.1]oct-3-yloxy)-4-methoxy-benzaldehyde | 131408-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-((1R,3R,5S)-Bicyclo[3.2.1]oct-3-yloxy)-4-methoxy-benzaldehyde
• CAS: 131408-38-3
• 化学式: C₁₆H₂₀O₃
• 分子量: 260.333
• InChiKey: FZMYEEQUSOCVTD-IMRBUKKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.47
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  3-((1R,3R,5S)-Bicyclo[3.2.1]oct-3-yloxy)-4-methoxy-benzaldehyde 在 二异丁基氢化铝 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 76.0h， 生成 1-[3-((1R,3R,5S)-Bicyclo[3.2.1]oct-3-yloxy)-4-methoxy-phenyl]-N¹-methyl-ethane-1,2-diamine
  参考文献：
  名称：

  Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones

  摘要：

  The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [H-3]rolipram to rat brain membranes and exhibit efficacy in preclinical models of antidepressant activity in mice, such as reducing immobility in the forced-swim test and reversing reserpine-induced hypothermia. Imidazolidinones 4 and 16 were found to be the most potent compounds studied.

  DOI：

  10.1021/jm00105a045
• 作为产物：
  描述：

  异香兰素 、 bicyclo[3.2.1]octanol-3 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 3-((1R,3R,5S)-Bicyclo[3.2.1]oct-3-yloxy)-4-methoxy-benzaldehyde
  参考文献：
  名称：

  Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl-2-imidazolidinones

  摘要：

  The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [H-3]rolipram to rat brain membranes and exhibit efficacy in preclinical models of antidepressant activity in mice, such as reducing immobility in the forced-swim test and reversing reserpine-induced hypothermia. Imidazolidinones 4 and 16 were found to be the most potent compounds studied.

  DOI：

  10.1021/jm00105a045