ethyl 2-amino-7-[1-(pyrrolidine-1-carbonyl)-3,6-dihydro-2H-pyridin-4-yl]-3H-1-benzazepine-4-carboxylate | 1386860-17-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: ethyl 2-amino-7-[1-(pyrrolidine-1-carbonyl)-3,6-dihydro-2H-pyridin-4-yl]-3H-1-benzazepine-4-carboxylate
• CAS: 1386860-17-8
• 化学式: C₂₃H₂₈N₄O₃
• 分子量: 408.5
• InChiKey: FVWFMRGTQKFFQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted Benzoazepines As Toll-Like Receptor Modulators
  申请人：Howbert James Jeffry

  公开号：US20140066432A1

  公开（公告）日：2014-03-06

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

  提供的是对调节Toll样受体TLR7和/或TLR8信号传导有用的组合物和方法。这些组合物和方法在治疗或预防疾病方面有用，包括癌症、自身免疫疾病、纤维化疾病、心血管疾病、传染病、炎症性疾病、移植排斥或移植物抗宿主病方面。
• SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
  申请人：VentiRx Pharmaceuticals, Inc.

  公开号：EP3208263A1

  公开（公告）日：2017-08-23

  Provided are benzazepine derivatives useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The benzazepine derivatives have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

  本文提供的苯并氮杂卓衍生物可用于调节通过 Toll 样受体 TLR7 和/或 TLR8 发出的信号。这些苯并氮杂卓衍生物可用于治疗或预防疾病，包括癌症、自身免疫性疾病、纤维化疾病、心血管疾病、传染性疾病、炎症性疾病、移植物排斥或移植物抗宿主疾病。
• US9718796B2
  申请人：——

  公开号：US9718796B2

  公开（公告）日：2017-08-01
• [EN] SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS<br/>[FR] BENZOAZÉPINES SUBSTITUÉES UTILISABLES COMME MODULATEURS DES RÉCEPTEURS DE TYPE TOLL
  申请人：VENTIRX PHARMACEUTICALS INC

  公开号：WO2012097173A2

  公开（公告）日：2012-07-19

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.