4-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)pyridine | 1258795-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)pyridine
• 英文别名: 4-bromo-N-(1-pyridin-4-ylethylideneamino)aniline
• CAS: 1258795-11-7
• 化学式: C₁₃H₁₂BrN₃
• 分子量: 290.162
• InChiKey: JQZXFOJUQUEIDM-UHFFFAOYSA-N

物化性质

• 熔点：
  160-165 °C(Solvent: Ethanol)
• 沸点：
  393.4±48.0 °C(predicted)
• 密度：
  1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)pyridine 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-bromo-2-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole
  参考文献：
  名称：

  Synthesis of 2,5-disubstituted-3-cyanoindoles

  摘要：

  An efficient synthesis of 2,5-disubstituted-3-cyanoindoles is described. This approach utilizes a highly selective iodination together with the modified Made lung reaction to generate an intermediate which can be readily transformed to more fully elaborated 2,5-disubstituted-3-cyanoindole templates that were previously difficult to access. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.009
• 作为产物：
  描述：

  4-乙酰吡啶 、 对溴苯肼 以 乙醇 为溶剂， 反应 2.0h， 以85%的产率得到4-(1-(2-(4-bromophenyl)hydrazineylidene)ethyl)pyridine
  参考文献：
  名称：

  Synthesis of 2,5-disubstituted-3-cyanoindoles

  摘要：

  An efficient synthesis of 2,5-disubstituted-3-cyanoindoles is described. This approach utilizes a highly selective iodination together with the modified Made lung reaction to generate an intermediate which can be readily transformed to more fully elaborated 2,5-disubstituted-3-cyanoindole templates that were previously difficult to access. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.009

文献信息

• NOVEL COMPOUNDS AS NADPH OXIDASE INHIBITORS
  申请人：GenKyoTex Suisse SA

  公开号：EP3628669A1

  公开（公告）日：2020-04-01

  The present invention is related to new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  这项发明涉及新化合物，其药物组成以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶）相关的疾病或症状。
• Open Vessel and Cooling while Heating Microwave-Assisted Synthesis of Pyridinyl <i>N</i>-Aryl Hydrazones
  作者：Giuseppe La Regina、Valerio Gatti、Francesco Piscitelli、Romano Silvestri

  DOI：10.1021/co100015b

  日期：2011.1.10

  We reported the first example of open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones. Compounds were prepared in excellent isolated yields (88-98%) in only 5 min, by reacting 4- and 2,4-(di) substituted phenylhydrazines, bearing both electron-donating (4-CH3, 4-OCH3) and -withdrawing (4-Cl, 4-Br, 4CF(3), 4-NO2, 2,4-Cl-2) groups with 2-, 3-, and 4-acetylpyridine. The method was successfully extended to other carbonyl compounds.