[3-(Butylthio)propyl]amine | 53056-87-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: [3-(Butylthio)propyl]amine
• 英文别名: 3-butylsulfanylpropan-1-amine
• CAS: 53056-87-4
• 化学式: C₇H₁₇NS
• mdl: MFCD12144238
• 分子量: 147.285
• InChiKey: FXIXKBWZQPKQLB-UHFFFAOYSA-N

物化性质

• 沸点：
  217.4±23.0 °C(Predicted)
• 密度：
  0.910±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [3-(Butylthio)propyl]amine 、 丙烯腈 生成 N1-(3-Butylsulfanyl-propyl)-propane-1,3-diamine
  参考文献：
  名称：

  Schuetz; Kurz; Pluempe, Arzneimittel-Forschung/Drug Research, 1971, vol. 21, # 6, p. 739 - 763

  摘要：

  DOI：

文献信息

• Inhibitors of MshC and Homologs Thereof, and Methods of Identifying Same
  申请人：Fahey Robert C.

  公开号：US20100022509A1

  公开（公告）日：2010-01-28

  The present invention utilizes three families of bacterial enzymes, which play a key role in mycothiol biosynthesis. The three families are bacterial cysteine:glucosaminyl inositol ligases (MshC) with catalytic ligase activity for ligation of glucosaminyl inositol and cysteine, bacterial acetyl-CoA:Cys-GlcN-Ins acetyltransferases (MshD) with catalytic activity for addition of an acetyl group to Cys-GlcN-Ins and bacterial MshA glycosyltransferase with catalytic activity for production of GlcNAc-Ins. The invention provides methods for using the mycothiol biosynthesis ligases, acetyltransferases or glycosyltransferases in drug screening assays to determine compounds that inhibit activity. The invention also provides inhibitors of the production or activity of the enzymes of mycothiol biosynthesis, and use of the inhibitors for treating microbial infection.

  本发明利用三种细菌酶家族，它们在肌硫醇生物合成中起着关键作用。这三个家族是：具有催化配体活性的细菌半胱氨酸：葡萄糖胺酰肌醇连接酶（MshC），用于连接葡萄糖胺酰肌醇和半胱氨酸；具有催化活性的细菌乙酰辅酶A：半胱氨酸-GlcN-Ins乙酰转移酶（MshD），用于向Cys-GlcN-Ins添加乙酰基；以及具有催化活性的细菌MshA糖基转移酶，用于生产GlcNAc-Ins。本发明提供了使用肌硫醇生物合成连接酶、乙酰转移酶或糖基转移酶进行药物筛选测定的方法，以确定抑制活性的化合物。本发明还提供了肌硫醇生物合成酶的产生或活性的抑制剂，并将其用于治疗微生物感染。
• BENZIMIDAZOLE DERIVATIVE
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0711768A1

  公开（公告）日：1996-05-15

  Disclosed are compounds represented by the following chemical formula (I) and pharmacologically acceptable salts thereof which are novel compounds useful as anticancer agents, antiviral agents or antimicrobial agents.

  所公开的是由以下化学式（I）代表的化合物及其药理学上可接受的盐类，它们是可用作抗癌剂、抗病毒剂或抗菌剂的新型化合物。
• Phenylbenzimidazole derivatives
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0719765A2

  公开（公告）日：1996-07-03

  An anticancer agent, an antiviral agent or an antimicrobial agent which contains, as an active ingredient for acting on DNA, a compound presented by the following formula (1) or its pharmacologically acceptable salt:

  一种抗癌剂、一种抗病毒剂或一种抗菌剂，其作用于 DNA 的活性成分含有下式（1）所示的化合物或其药理学上可接受的盐：
• PERYLENE TETRACARBOXYDIIMIDE DERIVATIVE
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP2471778A1

  公开（公告）日：2012-07-04

  Provided is a perylene tetracarboxylic diimide derivative represented by the following formula (1): In the formula (1), R1 means a linear or branched alkyl group having from 1 to 20 carbon atoms, R2 and R3 each independently mean a linear or branched alkyl group having from 2 to 6 carbon atoms, X1 and X2 each mean a hetero atom selected from an oxygen atom, sulfur atom or selenium atom, Y means a halogen atom or cyano group, m stands for a number of from 0 to 4, and n stands for a number of from 0 to 2.

  本发明提供了一种由下式（1）表示的过烯四羧酸二亚胺衍生物： 在式 (1) 中，R1 表示具有 1 至 20 个碳原子的直链或支链烷基，R2 和 R3 各自独立地表示具有 2 至 6 个碳原子的直链或支链烷基，X1 和 X2 各自表示选自氧原子、硫原子或硒原子的杂原子，Y 表示卤素原子或氰基，m 代表 0 至 4 的数字，n 代表 0 至 2 的数字。
• ORGANIC SEMICONDUCTOR MATERIAL, ORGANIC SEMICONDUCTOR THIN FILM, AND ORGANIC THIN FILM TRANSISTOR
  申请人：Dainichiseika Color & Chemicals Mfg. Co., Ltd.

  公开号：EP2495780A1

  公开（公告）日：2012-09-05

  Provided are an organic semiconductor material, organic semiconductor thin film and organic thin-film transistor, which contain a perylene tetracarboxylic diimide derivative represented by the following formula (1): In the formula (1), R1 means a linear or branched alkyl group having from 1 to 20 carbon atoms, R2 means a linear or branched alkyl group having from 2 to 6 carbon atoms, R3 means a linear or branched alkyl group having from 2 to 6 carbon atoms, X1 and X2 each mean a heteroatom selected from an oxygen atom, sulfur atom or selenium atom, Y means a halogen atom or cyano group, m stands for a number of from 0 to 4, and n stands for a number of from 0 to 2. Further, the alkyl groups represented by R1 and R2 may each be substituted with one or more fluorine atoms.

  本发明提供了一种有机半导体材料、有机半导体薄膜和有机薄膜晶体管，它们含有由下式（1）表示的过四羧酸二亚胺衍生物： 式（1）中，R1 指具有 1 至 20 个碳原子的直链或支链烷基，R2 指具有 2 至 6 个碳原子的直链或支链烷基，R3 指具有 2 至 6 个碳原子的直链或支链烷基，X1 和 X2 分别指选自氧原子、硫原子或硒原子的杂原子，Y 指卤素原子或氰基，m 代表 0 至 4 的数字，n 代表 0 至 2 的数字。此外，R1 和 R2 所代表的烷基可分别被一个或多个氟原子取代。