2-fluoro-4-iodo-N-methylaniline | 1260827-01-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-fluoro-4-iodo-N-methylaniline
• CAS: 1260827-01-7
• 化学式: C₇H₇FIN
• 分子量: 251.042
• InChiKey: XAXVOXWTZJYYCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-fluoro-4-iodo-N-methylaniline 、 2,3,4-三氟苯甲酸 在 lithium amide 作用下， 以 四氢呋喃 为溶剂， 以66%的产率得到3,4-difluoro-2-((2-fluoro-4-iodophenyl)(methyl)amino)benzoic acid
  参考文献：
  名称：

  [EN] NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF
  [FR] NOUVEAUX AMIDES ANTHRANILIQUES ET UTILISATION DE CES DERNIERS

  摘要：

  公开号：

  WO2015038743A9
• 作为产物：
  描述：

  2-氟-4-碘苯胺 、 sodium methylate 在 聚合甲醛 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 7.5h， 以54%的产率得到2-fluoro-4-iodo-N-methylaniline
  参考文献：
  名称：

  Structure activity relationships of anthranilic acid-based compounds on cellular and in vivo mitogen activated protein kinase-5 signaling pathways

  摘要：

  DOI：

  10.1016/j.bmcl.2018.05.029

文献信息

• Novel arylamino N-heteraryls as MEK inhibitors
  申请人：Goutopoulos Andreas

  公开号：US20070287709A1

  公开（公告）日：2007-12-13

  The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

  该发明提供了化学式(I)的新型芳基氨基N-杂环基MEK抑制剂：这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症和炎症。还公开了哺乳动物过度增殖性疾病的治疗以及含有这些化合物的制药组合物。
• NOVEL ARYLAMINO N-HETERARYL COMPOUNDS AS MEK INHIBITORS
  申请人：Goutopoulos Andreas

  公开号：US20100256149A1

  公开（公告）日：2010-10-07

  The invention provides novel arylamino N-heteroaryl MEK inhibitors of Formula (I): Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.

  该发明提供了公式（I）的新型芳基氨基N-杂环基MEK抑制剂：这些化合物是MEK抑制剂，可用于治疗高增殖性疾病，如癌症和炎症。还公开了哺乳动物高增殖性疾病的治疗方法，以及含有这些化合物的药物组合物。
• NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF
  申请人：THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  公开号：US20160221975A1

  公开（公告）日：2016-08-04

  Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.

  本发明揭示了具有以下公式的蒽酰胺衍生物。本发明还揭示了包括该蒽酰胺衍生物的组合物以及使用该蒽酰胺衍生物制备药物的用途。此外，本发明还揭示了通过向受试者施用揭示的蒽酰胺衍生物的有效量来抑制或治疗癌症，抑制或逆转上皮-间充质细胞转化，并/或抑制MEK1/2和/或MEK 5酶活性的方法。
• NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3345907A1

  公开（公告）日：2018-07-11

  To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the prevention and/or treatment of a disease involving HER2, particularly, cancer, on the basis of the HER2 inhibitory effect. The present invention provides a compound of formula (I) wherein X, Y, Z1, Z2, Z3, Z4, W, n, R1, R2, and R3 have meanings as defined in the present specification, or a salt thereof.

  提供一种具有 HER2 抑制作用和细胞抑制作用的新型化合物。本发明还旨在提供一种基于 HER2 抑制作用、可用于预防和/或治疗涉及 HER2 的疾病（尤其是癌症）的药物。 本发明提供了式(I)化合物，其中X、Y、Z1、Z2、Z3、Z4、W、n、R1、R2和R3具有本说明书中定义的含义，或其盐。
• 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONE DERIVATIVE AS WEE1 INHIBITOR
  申请人：Shijiazhuang Sagacity New Drug Development Co., Ltd.

  公开号：EP3572413B1

  公开（公告）日：2021-11-03