[4-({N-ethyl[6-ethyl-2'-propyl-4'-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)biphenyl-3-yl]amino}methyl)-2-hydroxymethylphenyl]methanol | 915004-37-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: [4-({N-ethyl[6-ethyl-2'-propyl-4'-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)biphenyl-3-yl]amino}methyl)-2-hydroxymethylphenyl]methanol
• 英文别名: 2-[4-[5-[[3,4-Bis(hydroxymethyl)phenyl]methyl-ethylamino]-2-ethylphenyl]-3-propylphenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS: 915004-37-4
• 化学式: C₃₁H₃₅F₆NO₃
• 分子量: 583.614
• InChiKey: CCAHOQBJQOAVGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  63.9
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Triaromatic vitamin D analogues
  申请人：——

  公开号：US20030195259A1

  公开（公告）日：2003-10-16

  The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): 1 and also to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.

  该发明涉及一种新颖且有用的工业产品，即一般式(I)的三芳基化合物，它们是维生素D类似物，同时涉及一种制备它们的方法以及它们在用于人类或兽医药物的制剂中的使用，或者在化妆品制剂中的使用。
• Pharmaceutical compositions comprising organopolysiloxane elastomers and solubilized bioactive compounds
  申请人：Barthez Nathalie

  公开号：US20080194528A1

  公开（公告）日：2008-08-14

  Stable, anhydrous pharmaceutical compositions contain an organopolysiloxane elastomer and, as bioactive ingredient, at least one vitamin D compound in a solubilized form, and are useful for the topical treatment of psoriasis and other skin disorders/afflictions.
• US6924400B2
  申请人：——

  公开号：US6924400B2

  公开（公告）日：2005-08-02