diethylammonium hydrogencarbonate | 15715-56-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: diethylammonium hydrogencarbonate
• 英文别名: carbonic acid;N-ethylethanamine
• CAS: 15715-56-7
• 化学式: CHO₃*C₄H₁₂N
• 分子量: 135.163
• InChiKey: KJBMLEDGPWAQBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.52
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  77
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diethylammonium hydrogencarbonate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 N'-(N-acetyl-sulfanilyl)-N,N-diethyl-guanidine
  参考文献：
  名称：

  Production of n4-acetyl sulfguanidines

  摘要：

  公开号：

  US02463793A1
• 作为产物：
  描述：

  二氧化碳 、 二乙胺 以 水 为溶剂， 生成 diethylammonium hydrogencarbonate
  参考文献：
  名称：

  Synthesis of N4-Substituted Derivatives of 1-[2-(Phosphonomethoxy)ethyl]cytosine and Its Diisopropyl Ester as a Model Reaction for the Synthesis of N4-Substituted Derivatives of Cidofovir

  摘要：

  我们研究了1-[2-(磷酸甲氧基)乙基]胞嘧啶（1）及其二异丙酯（2）与三乙胺硫酸氢盐在60%水甲醇中的反应。在一些一级或二级胺盐的存在下，反应在25-70℃下产生了转氨化衍生物4a-4e和5a，5b作为主要产物，伴随尿嘧啶化合物。然而，对于某些胺而言，反应失败了。

  DOI：

  10.1135/cccc20052066
• 作为试剂：
  描述：

  亚甲基双膦酰二氯 、 (2R,3R,4S,5R)-2-[6-(benzylamino)-2-methylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol 在 磷酸三甲酯 、 水 、 diethylammonium hydrogencarbonate 作用下， 反应 5.25h， 生成 (((((2R,3S,4R,5R)-5-(6-(benzylamino)-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
  参考文献：
  名称：

  [EN] MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF
  [FR] MODULATEURS DE L'ECTO-5 '-NUCLÉOTIDASE ET LEUR UTILISATION

  摘要：

  公开号：

  WO2017120508A8

文献信息

• Fichter; Becker, Chemische Berichte, 1911, vol. 44, p. 3482
  作者：Fichter、Becker

  DOI：——

  日期：——
• Production of n4-acetyl sulfguanidines
  申请人：RHONE POULENC SA

  公开号：US02463793A1

  公开（公告）日：1949-03-08
• Control of the Photocatalytic Activity of Bimetallic Complexes of Pyropheophorbide-<i>a</i> by Nucleic Acids
  作者：Dumitru Arian、Larisa Kovbasyuk、Andriy Mokhir

  DOI：10.1021/ic201408h

  日期：2011.12.5

  Photo catalytic activity of a photosensitizer (PS) in an oligodeoxyribonucleotide duplex 5'-PS similar to ODN1/ODN2 similar to Q-3' is inhibited because of close proximity of a quencher Q, The ODN2 in this duplex is selected to be longer than the ODN1. Therefore, in the presence of a nucleic acid (analyte), which is fully complementary to the ODN2 strand, the duplex is decomposed with formation of an analyte/ODN2Q duplex and a catalytically active, single stranded PS similar to ODN1. In this way the catalytic activity of the PS can be controlled by the specific nucleic acids. We applied this reaction earlier for the amplified detection of ribonucleic acids in live cells (Arian, D.; Clo, E.; Gothelf, K; Mokhir, A. Chem.- Ear J. 2010, 16(1), 288). As a photosensitizer (PS) we used In3+(pyropheophorbide-a)chloride and as a quencher (Q) - Black-Hole-Quencher-3 (BHQ-3). The In3+ complex is a highly active photocatalyst in aqueous solution. However, it can coordinate additional ligands containing thiols (e.g., proteins, peptides, and aminoacids), that modulate properties of the complex itself and of the corresponding bio- molecules. These possible interactions can lead to undesired side effects of nucleic acid controlled photocatalysts (PS similar to ODN1/ODN2-Q) in live cells. In this work we explored the possibility to substitute the In3+ complex for those ones of divalent metal ions, Zn2+ and Pd2+, which exhibit lower or no tendency to coordinate the fifth ligand. We found that one of the compounds tested (Pd(pyropheophorbide-a) is as potent and as stable photosensitizer as its In3+ analogue, but does not coordinate additional ligands that makes it more suitable for cellular applications. When the Pd complex was introduced in the duplex PS similar to ODN1/ODN2-Qas a PS, its photocatalytic activity could be controlled by nucleic acids as efficiently as that of the corresponding In3+ complex.
• Allyl Protection in the Synthesis of Oligodeoxyribonucleotide Phosphorothioates
  作者：Yoshihiro Hayakawa、Masaaki Hirose、Ryoji Noyori

  DOI：10.1080/15257779408012156

  日期：1994.7

  Allyl and allyloxycarbonyl groups serve as useful protectors for internucleotide linkages and nucleoside bases, respectively, in the synthesis of partially or fully phosphorothioate-modified oligodeoxyribonucleotides.
• Synthesis of N4-Substituted Derivatives of 1-[2-(Phosphonomethoxy)ethyl]cytosine and Its Diisopropyl Ester as a Model Reaction for the Synthesis of N4-Substituted Derivatives of Cidofovir
  作者：Šárka Chalupová、Antonín Holý、Milena Masojídková

  DOI：10.1135/cccc20052066

  日期：——

  We have studied the reaction of 1-[2-(phosphonomethoxy)ethyl]cytosine (1) and its diisopropyl ester (2) with triethylammonium hydrogensulfite in 60% aqueous methanol. In the presence of some primary or secondary amine salts, at 25-70 °C, this reaction affords transaminated derivatives 4a-4e and 5a, 5b as main products accompanied by uracil compounds. However, with certain amines the reaction failed.

  我们研究了1-[2-(磷酸甲氧基)乙基]胞嘧啶（1）及其二异丙酯（2）与三乙胺硫酸氢盐在60%水甲醇中的反应。在一些一级或二级胺盐的存在下，反应在25-70℃下产生了转氨化衍生物4a-4e和5a，5b作为主要产物，伴随尿嘧啶化合物。然而，对于某些胺而言，反应失败了。