p-(N,N-Dimethylamino)-benzyl-phenylsulfon | 13640-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-(N,N-Dimethylamino)-benzyl-phenylsulfon
• 英文别名: p-Dimethylaminobenzylphenylsulfon；4-benzenesulfonylmethyl-N,N-dimethyl-aniline；4-Benzolsulfonylmethyl-N,N-dimethyl-anilin；N,N-Dimethyl-4-[(phenylsulfonyl)methyl]benzenamine；4-(benzenesulfonylmethyl)-N,N-dimethylaniline
• CAS: 13640-68-1
• 化学式: C₁₅H₁₇NO₂S
• 分子量: 275.371
• InChiKey: ICWRGOJDJJXKJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯亚磺酰氯 、 4-(二甲氨基)苄醇 以 氯仿 为溶剂， 反应 7.0h， 以76%的产率得到p-(N,N-Dimethylamino)-benzyl-phenylsulfon
  参考文献：
  名称：

  An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides

  摘要：

  In the absence of external catalysts and additives, a broad range of benzylic and allylic alcohols react with various sulfinyl chlorides to afford structurally diversified benzylic and allylic sulfones in moderate to excellent yields, and importantly, a catalysis with byproduct HCl is involved in this new protocol for sulfone synthesis.

  DOI：

  10.1021/jo901974h

文献信息

• Mechanism of formation of p-aminobenzyl aryl sulfides, selenides, or sulfones by the acid-catalyzed condensation of aromatic amines with formaldehyde and arenethiols, selenols, or sulfinic acids
  作者：Ithamar E. Pollak、Gerald F. Grillot

  DOI：10.1021/jo01285a036

  日期：1967.10
• Mangini et al., Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1956, vol. 14, p. 81,93
  作者：Mangini et al.

  DOI：——

  日期：——
• An Expeditious Entry to Benzylic and Allylic Sulfones through Byproduct-Catalyzed Reaction of Alcohols with Sulfinyl Chlorides
  作者：Hai-Hua Li、De-Jun Dong、Yin-Huan Jin、Shi-Kai Tian

  DOI：10.1021/jo901974h

  日期：2009.12.18

  In the absence of external catalysts and additives, a broad range of benzylic and allylic alcohols react with various sulfinyl chlorides to afford structurally diversified benzylic and allylic sulfones in moderate to excellent yields, and importantly, a catalysis with byproduct HCl is involved in this new protocol for sulfone synthesis.