2-Amino-6-(2-fluorophenyl)-4-(furan-2-yl)pyridine-3-carboxamide | 400031-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Amino-6-(2-fluorophenyl)-4-(furan-2-yl)pyridine-3-carboxamide
• CAS: 400031-61-0
• 化学式: C₁₆H₁₂FN₃O₂
• 分子量: 297.289
• InChiKey: QQQVQZHTQGZATH-UHFFFAOYSA-N

物化性质

• 沸点：
  430.8±45.0 °C(Predicted)
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Amino-6-(2-fluorophenyl)-4-(furan-2-yl)pyridine-3-carboxamide 在 ammonium sulfate 作用下， 以 二苯醚 、 甲苯 为溶剂， 反应 4.0h， 生成 7-(2-Fluoro-phenyl)-5-furan-2-yl-3-(2-methoxy-phenyl)-2-trimethylsilanylsulfanyl-3H-pyrido[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270
• 作为产物：
  描述：

  6-(2-fluorophenyl)-4-(furan-2-yl)-2-imino-1,2-dihydropyridine-3-carbonitrile 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 2-Amino-6-(2-fluorophenyl)-4-(furan-2-yl)pyridine-3-carboxamide
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270