ethyl 2-(3-chlorophenylamino)-4-ethylpyrimidine-5-carboxylate | 862460-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: ethyl 2-(3-chlorophenylamino)-4-ethylpyrimidine-5-carboxylate
• 英文别名: Ethyl 2-(3-chloroanilino)-4-ethylpyrimidine-5-carboxylate
• CAS: 862460-73-9
• 化学式: C₁₅H₁₆ClN₃O₂
• 分子量: 305.764
• InChiKey: IGLQGACLMPLVQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 2- (PHENYLAMINO) -PYRIMIDIN-5-AMIDES AS CANNABINOID 2 RECEPTORS MODULATORS FOR THE TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS<br/>[FR] 2-(PHENYLAMINO)-PYRIMIDIN-5-AMIDES UTILISES COMME MODULATEURS DES RECEPTEURS CANNABINOIDES 2 DANS LE TRAITEMENT DE TROUBLES IMMUNS OU INFLAMMATOIRES
  申请人：GLAXO GROUP LTD

  公开号：WO2005075440A1

  公开（公告）日：2005-08-18

  The present invention relates to novel pyrimidine derivatives such as compounds of formula (I), and the use of such compounds or pharmaceutical compositions thereof in the treatment of diseases, particularly pain, which are mediated by the activity of the cannabinoid 2 receptor.

  本发明涉及新型嘧啶衍生物，如式(I)化合物，以及利用这些化合物或其药物组合物在治疗疾病中的应用，尤其是通过大麻素2受体活性介导的疼痛。
• 2-(Phenylamino)-Pyrimidin-5-Amides As Cannabinoid 2 Receptors Modulators for the Treatment of Immune or Inflammatory Disorders
  申请人：Eatherton Andrew John

  公开号：US20090264452A1

  公开（公告）日：2009-10-22

  The present invention relates to novel pyrimidine derivatives such as compounds of the formula (I): and the use of such compounds or pharmaceutical compositions thereof in the treatment of diseases, particularly pain, which are mediated by the activity of the cannabinoid 2 receptor.

  本发明涉及新型嘧啶衍生物，例如式(I)化合物，以及这些化合物或其制药组合物在治疗疾病，特别是由大麻素2受体活性介导的疼痛方面的应用。
• 2-(PHENYLAMINO)-PYRIMIDIN-5-AMIDES AS CANNABINOID 2 RECEPTORS MODULATORS FOR THE TREATMENT OF IMMUNE OR INFLAMMATORY DISORDERS.
  申请人：GLAXO GROUP LIMITED

  公开号：EP1711475A1

  公开（公告）日：2006-10-18