2,6-bis{[N-isopropyl-N′-methylene]imidazole-1-ylidene-2-thione}pyridine | 1375075-07-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis{[N-isopropyl-N′-methylene]imidazole-1-ylidene-2-thione}pyridine
• 英文别名: 2,6-bis(N-isopropyl-N’-methyleneimidazole-2-thione)pyridine；2,6-bis(N-isopropyl-N'-methyleneimidazole-2-thione)pyridine；1-Propan-2-yl-3-[[6-[(3-propan-2-yl-2-sulfanylideneimidazol-1-yl)methyl]pyridin-2-yl]methyl]imidazole-2-thione；1-propan-2-yl-3-[[6-[(3-propan-2-yl-2-sulfanylideneimidazol-1-yl)methyl]pyridin-2-yl]methyl]imidazole-2-thione
• CAS: 1375075-07-2
• 化学式: C₁₉H₂₅N₅S₂
• 分子量: 387.573
• InChiKey: XZXCFOOBGYNEAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-bis{[N-isopropyl-N′-methylene]imidazole-1-ylidene-2-thione}pyridine 、 zinc(II) chloride 以 二氯甲烷 为溶剂， 以99%的产率得到chloro-(.eta**(3)-S,S,N)-[2,6-bis(N-isopropyl-N'-methyleneimidazole-2-thione)pyridine]zinc(II) tetrachlorozincate
  参考文献：
  名称：

  Miecznikowski, John R.; Lo, Wayne; Lynn, Matthew A., Inorganica Chimica Acta, 2012, vol. 387, p. 25 - 36

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-bis[(3-isopropylimidazolium-1-yl)methyl]pyridine dibromide 在 sodium acetate 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 以 乙腈 为溶剂， 反应 168.5h， 以70%的产率得到2,6-bis{[N-isopropyl-N′-methylene]imidazole-1-ylidene-2-thione}pyridine
  参考文献：
  名称：

  Syntheses, characterization, density functional theory calculations, and activity of tridentate SNS zinc pincer complexes based on bis-imidazole or bis-triazole precursors

  摘要：

  A series of tridentate pincer ligands, each possessing two sulfur-and one nitrogen-donor functionalities (SNS), based on bis-imidazole or bis-triazole salts were metallated with ZnCl2 to give new tridentate SNS pincer zinc(II) complexes [(SNS)ZnCl](+). The zinc complexes serve as models for the zinc active site in liver alcohol dehydrogenase (LADH) and were characterized with single crystal X-ray diffraction, H-1, C-13, and HSQC NMR spectroscopies, electrospray mass spectrometry, and elemental analysis. The zinc complexes feature SNS donor atoms and pseudotetrahedral geometry about the zinc center, as is seen for liver alcohol dehydrogenase. The bond lengths and bond angles of the zinc complexes correlate well to those in horse LADH. The SNS ligand precursors were characterized with H-1, C-13, and HSQC NMR spectroscopies, elemental analysis, and cyclic voltammetry, and were found to be redox active. Gaussian calculations were performed and agree with the experimentally observed oxidation potentials for the pincer ligand precursors. The zinc complexes were screened for the reduction of electron-poor aldehydes in the presence of a hydrogen donor, 1-benzyl-1,4-dihydronicotinamide (BNAH), and it was determined that they enhance the reduction of electron-poor aldehydes. The SNS zinc pincer complexes with bis-triazole ligand precursors exhibit higher activity for the reduction of 4-nitrobenzaldehyde than do SNS zinc pincer complexes with bis-imidazole ligand precursors. Quantitative stoichiometric conversion was seen for the reduction of pyridine-2-carboxaldehyde via SNS zinc pincer complexes with either bis-imidazole or bis-triazole ligand precursors. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.12.047

文献信息

• Synthesis, characterization, and computational study of three-coordinate SNS-copper(I) complexes based on bis-thione precursors
  作者：John R. Miecznikowski、Matthew A. Lynn、Jerry P. Jasinski、Eric Reinheimer、Daniel W. Bak、Mekhala Pati、Elizabeth E. Butrick、Anne Elise R. Drozdoski、Kerry A. Archer、Christine E. Villa、Elise G. Lemons、Erin Powers、Margaret Siu、Camile D. Gomes、Kaitlyn N. Morio

  DOI：10.1080/00958972.2014.883070

  日期：2014.1.2

  A series of tridentate pincer ligands, each possessing two sulfur and one nitrogen donor (SNS), based on bis-imidazolyl or bis-triazolyl salts were metallated with CuCl2 to give new tridentate SNS pincer copper(I) complexes [(SNS)Cu]+. These orange complexes exhibit a three-coordinate pseudo-trigonal-planar geometry in copper. During the formation of these copper(I) complexes, disproportionation is

  一系列基于双咪唑基或双三唑基盐的三齿钳状配体（每个配体具有两个硫和一个氮供体（SNS））用 CuCl2 金属化，得到新的三齿 SNS 钳状铜（I）配合物 [(SNS)Cu] +。这些橙色配合物在铜中表现出三坐标伪三角平面几何形状。在这些铜 (I) 络合物的形成过程中，随着铜 (II) 盐前体转化为 Cu(I) [(SNS)Cu]+ 阳离子和 [CuCl4]2- 抗衡阴离子，观察到歧化。[(SNS)Cu]+ 配合物通过单晶 X 射线衍射、电喷雾质谱、EPR 光谱、衰减全反射红外光谱、UV-Vis 光谱、循环伏安法和元素分析进行​​表征。EPR 光谱与各向异性 Cu(II) 信号一致，在低场区域 (g||) 中有四个超精细分裂，g 值与四氯铜酸盐的存在一致。各种电子跃迁在配合物的 UV-Vis 光谱中是显而易见的，并且起源于含铜的阳离子和阴离子。密度泛函计算支持 SNS 结合的性质，允许分配存在于
• Copper(I) SNS pincer complexes: Impact of ligand design and solvent coordination on conformer interconversion from spectroscopic and computational studies
  作者：Matthew A. Lynn、John R. Miecznikowski、Jerry P. Jasinski、Manpreet Kaur、Brandon Q. Mercado、Eric Reinheimer、Emilse M. Almanza、Rami M. Kharbouch、Michael R. Smith、Samantha E. Zygmont、Nicole F. Flaherty、Amber C. Smith

  DOI：10.1016/j.ica.2019.118996

  日期：2019.9

  syntheses and detailed characterizations (X-ray crystallography, NMR spectroscopy, cyclic voltammetry, infrared spectroscopy, electrospray mass spectrometry, and elemental analyses) of two new Cu(I) pincer complexes are reported. The pincer ligand coordinates through one nitrogen and two sulfur donor atoms and is based on bis-imidazole or bis-triazole precursors. These tridentate SNS ligands incorporate

  摘要报道了两种新型Cu（I）钳形配合物的合成和详细表征（X射线晶体学，NMR光谱，循环伏安法，红外光谱，电喷雾质谱和元素分析）。夹钳配体通过一个氮和两个硫供体原子配位，并且基于双咪唑或双三唑前体。这些三齿SNS配体结合了吡啶和硫酮取代的咪唑或三唑官能团，并具有连接的亚甲基单元，这些亚甲基单元可为配体主链提供柔韧性并实现高咬合角结合。这些配合物和类似的锌（II）SNS系统的可变温度1H NMR分析表明，它们在溶液中都是流动的，可以测定ΔGexp•和ΔSexp•。
• Synthesis, Single Crystal Structure and Spectroscopic Characterization of a Nickel(II) Complex that Contains a SNS Tridentate Ligand
  作者：John R. Miecznikowski、Emma E. Mircovich、Natalia R. Bertolotti、Michael J. Corbett、Jerry P. Jasinski、Eric Reinheimer

  DOI：10.1007/s10870-021-00919-9

  日期：2022.9

  A nickel(II) complex that contains a tridentate SNS ligand was prepared in 67% yield. The tridentate ligand coordinates through one nitrogen and two sulfur donor atoms and is based on a bis-imidazole precursor. The tridentate SNS ligands incorporate pyridine and thione-substituted imidazole moieties. The complex was characterized using single crystal X-ray diffraction, elemental analysis, magnetic

  以 67% 的产率制备了含有三齿 SNS 配体的镍 (II) 配合物。三齿配体通过一个氮和两个硫供体原子进行配位，并且基于双咪唑前体。三齿 SNS 配体包含吡啶和硫酮取代的咪唑部分。使用单晶 X 射线衍射、元素分析、磁化率、ESI 质谱、NMR ( 1 H、13 C 1 H} 和 HSQC) 光谱和紫外-可见光谱对该配合物进行了表征。镍 (II) 配合物是具有氯桥配体的二聚体。有趣的是，先前报道的相应的锌（II）、铜（I）和钴（II）配合物是单体，配位数从三到五不等。 图形概要