acetic acid 2-(acetylbenzylamino)ethyl ester | 15568-59-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetic acid 2-(acetylbenzylamino)ethyl ester
• 英文别名: 2-(N-benzylacetamido)ethyl acetate；N--acetamid；N-(2-Acetoxyethyl)-N-benzyl-acetamid；N-[Benzyl-(β-acetoxyaethyl)]-acetamid
• CAS: 15568-59-9
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.283
• InChiKey: VEJCZZRSWXMKKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.61
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  乙酸酐 、 N-苄基乙醇胺 在 poly(N-vinylimidazole) 作用下， 以 neat (no solvent) 为溶剂， 反应 0.25h， 以98%的产率得到acetic acid 2-(acetylbenzylamino)ethyl ester
  参考文献：
  名称：

  聚（N-乙烯基咪唑）是在无溶剂条件下将醇，酚，硫醇和胺乙酰化的有效催化剂

  摘要：

  聚（N-乙烯基咪唑）能够促进多种功能化醇，酚，硫醇和胺的瞬时定量乙酰化醋酸酐在室温下于无溶剂条件下进行。这种新方法始终具有出色的收率，并且催化剂可以重复使用和回收多次。此外，反应甚至可以更大规模地进行。

  DOI：

  10.1039/c2ra21295a

文献信息

• 4-Imidazol-1-yl-butane-1-sulfonic acid ionic liquid: Synthesis, structural analysis, physical properties and catalytic application as dual solvent-catalyst
  作者：Nader Ghaffari Khaligh、Taraneh Mihankhah、Mohd Rafie Johan、Joon Ching Juan

  DOI：10.1080/10426507.2018.1487426

  日期：2019.9.2

  Abstract 4-Imidazol-1-yl-butane-1-sulfonic acid (ImBu-SO3H) has been successfully synthetized and fully characterized by FT-IR and high-resolution NMR spectroscopy (1H, 13C). The “plausible” alternative structures of ImBu-SO3H were discussed on the basis of its NMR data. The ionic liquid showed interesting dual solvent-catalyst property, which was studied experimentally for the acetylation of a variety

  摘要 4-Imidazol-1-yl-butane-1-sulfonic acid (ImBu-SO3H) 已成功合成并通过 FT-IR 和高分辨率 NMR 光谱 (1H, 13C) 进行了充分表征。ImBu-SO3H 的“合理”替代结构在其 NMR 数据的基础上进行了讨论。离子液体显示出有趣的双溶剂-催化剂性质，实验研究了其乙酰化各种官能化的醇、酚、硫醇、胺和 α-生育酚 (α-CTP) 作为维生素 E 的最活性形式与乙酸酐并且在很短的反应时间内提供了良好的收率。ImBu-SO3H 通过产品萃取成功回收，随后 5 次运行的平均回收率为 82%。即使在连续五次运行后，回收的 ImBu-SO3H 的催化活性也几乎没有损失。图形概要
• A succinimide-N-sulfonic acid catalyst for acetylation reactions in absence of a solvent
  作者：Farhad SHIRINI、Nader Ghaffari KHALIGH

  DOI：10.1016/s1872-2067(11)60499-3

  日期：2013.4

  Abstract A small amount of succinimide-N-sulfonic acid efficiently catalyzed the acetylation of a variety alcohols, phenols, thiols, amines and aldehydes with acetic anhydride at room temperature under solvent free conditions. This catalyst has the advantages of excellent yields and short reaction times and the reaction can be carried out on a large scale, which makes it potentially useful for industrial

  摘要 在室温、无溶剂条件下，少量的琥珀酰亚胺-N-磺酸可有效催化多种醇类、酚类、硫醇类、胺类和醛类与乙酸酐的乙酰化反应。该催化剂具有收率高、反应时间短等优点，反应可以大规模进行，具有潜在的工业应用价值。
• Reactions of Aziridines with Acetyl Chloride and Related Compounds
  作者：Itaru Okada、Toshio Takahama、Rokuro Sudo

  DOI：10.1246/bcsj.43.2591

  日期：1970.8

  When aziridines (1) were treated with acetyl compounds, such as acetyl chloride, acetic acid, acetic anhydride, and thioacetic acid, the corresponding acetamide derivatives were obtained in good yields. In the case of acetyl chloride, some derivatives of N-(2-chloroethyl)acetamide (5) were found to be unstable in the face of moisture; they were easily hydrolyzed to give N-(2-hydroxyethyl) acetamide

  当氮丙啶类化合物(1)用乙酰基化合物如乙酰氯、乙酸、乙酸酐和硫代乙酸处理时，相应的乙酰胺衍生物收率良好。在乙酰氯的情况下，发现 N-(2-氯乙基)乙酰胺 (5) 的一些衍生物在水分面前不稳定；它们很容易水解得到 N-(2-羟乙基) 乙酰胺盐酸盐 (3)。讨论了 N-(2-巯基乙基)-N-苄基乙酰胺 (12) 的 NMR 谱。
• Preparation, characterization and use of poly(4-vinylpyridinium) perchlorate as a new, efficient, and versatile solid phase catalyst for acetylation of alcohols, phenols and amines
  作者：Nader Ghaffari Khaligh

  DOI：10.1016/j.molcata.2012.05.021

  日期：2012.11

  Poly(4-vinylpyridine) perchlorate, is a supported, recyclable, eco-benign catalyst for the reaction acetylation of structurally diverse alcohols, phenols and amines at room temperature under solvent-free conditions. The catalyst was studied by FT-IR. X-ray diffraction, Scanning Electron Microscope and Thermo-gravimetric Analyses. All the products were extensively characterized by H-1 NMR, FT-IR, GC-MS and melting point analyses. The catalyst can be recovered and reused without loss of activity. The workup of the reaction consists of a simple filtration, followed by concentration of the crude product and purification. It is important to point out that a large-scale reaction is possible using a same amount of catalyst. (C) 2012 Elsevier B.V. All rights reserved.