4-碘辛二酰苯胺氧肟酸 | 1219807-87-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-碘辛二酰苯胺氧肟酸
• 英文名称: N~1~-Hydroxy-N~8~-(4-iodophenyl)octanediamide
• 英文别名: N'-hydroxy-N-(4-iodophenyl)octanediamide
• CAS: 1219807-87-0
• 化学式: C₁₄H₁₉IN₂O₃
• 分子量: 390.22
• InChiKey: BYVHZKAHBXINPL-UHFFFAOYSA-N

物化性质

• 密度：
  1.579±0.06 g/cm3(Predicted)
• 溶解度：
  不溶于水；不溶于乙醇； DMSO 中≥1.67 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Treatment of neurodegenerative diseases and cancer of the brain with SAHA
  申请人：Sloan-Kettering Institute for Cancer Research

  公开号：EP2269609A2

  公开（公告）日：2011-01-05

  A composition comprising suberoylanilide hydroxamic acid (SAHA) represented by the following structure: or a pharmaceutically acceptable salt or hydrate thereof, and a Pharmaceutical acceptable carrier or diluent, for use in the treatment of brain cancer in a mammal, wherein the composition is formulated for oral administration.

  一种包含由以下结构表示的亚伯酰苯胺羟肟酸（SAHA）的组合物： 或其药学上可接受的盐或水合物，以及药学上可接受的载体或稀释剂，用于治疗哺乳动物的脑癌，其中该组合物配制成口服给药。
• TREATMENT OF NEURODEGENERATIVE DISEASES AND CANCER OF THE BRAIN
  申请人：Sloan-Kettering Institute For Cancer Research

  公开号：EP1443928B1

  公开（公告）日：2011-07-27
• [EN] TREATMENT OF NEURODEGENERATIVE DISEASES AND CANCER OF THE BRAIN<br/>[FR] TRAITEMENT DES MALADIES NEURODEGENERATIVES ET DU CANCER DU CERVEAU
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2003032921A2

  公开（公告）日：2003-04-24

  The present application is directed to a method of inhibiting HDAC in the brain of a mammal. The method comprises administering to a mammal a HDAC inhibiting amount of a histone deacetylase inhibitor compound. The present application is further directed to a method of treating diseases of the central nervous system (CNS) comprising administering to a individual in need of treatment a therapeutically effective amount of an inhibitor of HDAC. In particular embodiments, the CNS disease is a neurodegenerative disease. In further embodiments, the neurogenerative disease is an inherited neurodegenerative disease, such as those inherited neurodegenerative diseases which are polyglutamine expansion diseases. In other embodiments, the disorder is cancer of the brain. The individual is a mammal, such as a primate or human.